Drug Discovery World is the global voice for the drug discovery community. From research stage to clinical trials the brand covers the scientific and commercial process involved in getting a drug to market – research, target identification and validation, drug molecule identification, lead molecule optimisation, pre-clinical research, clinical… Read More
Advancements in technology, and in particular, developments in artificial intelligence (AI) are revolutionising the way that we live our lives. Up to now, we have used it to help us find the quickest route home or to search the Internet, but we now need to look much further. Read More
The Personalized Medicine Coalition The Personalized Medicine Coalition (PMC), representing a broad spectrum of academic, industrial, patient, provider, and payer communities, seeks to advance the understanding and adoption of personalized medicine concepts and products for the benefit of patients. As part of its… Read More
Collaborative Research Leads To New Understanding Of Biomarkers By Dr Max Ryadnov and Professor Jason Crain A new collaborative research paper sheds light on the way antibodies distinguish between different but closely related ‘biomarkers’ – in this case protein fragments which reveal information about the condition of the… Read More
Measuring Silicone Oil Interaction With Protein Using Hound Sponsored by Unchained Labs Many biologic drugs are lipophilic, meaning they are prone to strong negative interactions with the silicone oil used to lubricate prefilled syringes and vials. Protein – silicone oil interactions can cause protein aggregation and… Read More
Guidelines & Recommendations For Analyzing and Interpreting GPCR Second Messenger Data Sponsored by CisBio The question of choosing which methods to use for analyte quantification (signal vs concentration determination, parameters, and format) continues to generate heated debates and divergent understanding. Today, there is still… Read More
Unleashing High-Throughput Reaction Screening The Unchained way Sponsored by Unchained Labs A successful high-throughput approach to reaction screening requires rational and systematic exploration of a broad set of variables to achieve optimization expeditiously. There are many types of potential variables that can be screened. Even with… Read More
Stem Cell Differentiation By Dr Lilian Hook Stem cells are extraordinary cells, capable of both self-renewal and differentiation to mature somatic cells in vivo and in vitro (1,2). They have many features and advantages which could revolutionise drug development and healthcare applications. Read More
Phenotypic Drug Discovery With High Content Screening Sponsored by PerkinElmer Early drug discovery used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system – cells, tissue, or organisms – and asking the question, did this entity affect the phenotype?… Read More
Meet Big Tuna: Automated, Versatile Buffer Exchange Sponsored by Unchained Labs Conventional exchange methods are labor-intensive, prone to inconsistency, and difficult to manage in larger numbers. Introduction The critical process of screening formulation buffers to optimize stability is labor intensive… Read More
Meet Stunner: The One-Shot Protein Concentration and Sizing Combo Sponsored by Unchained Labs Stunner pulls double-duty so you don’t have to. It’s the one and only system that combines high-speed UV/Vis spectral analysis and Dynamic Light Scattering (DLS) for quantifying concentration and nailing down protein stability. Read More
Targeting Energy Metabolism for Cancer Therapeutic Discovery using Agilent Seahorse XF Technology Sponsored by Agilent This white paper discusses targeting energy metabolism for cancer therapeutic discovery using Agilent Seahorse XF technology. Abstract Altered energy metabolism is now recognized as a driver… Read More
Advanced Therapeutic Antibody Discovery with Multiplexed Screening Sponsored by Sartorius Antibody-based therapeutics are the fastest growing and most successful therapeutic modality for treating diseases such as cancer, cardiovascular disease, autoimmune disorders and infectious disease. It is predicted that by the year 2020 there will be 70… Read More
Gaining Insights Into Disease Biology for Target Identification and Validation Sponsored by Agilent Dysfunctional energy metabolism is associated with many different diseases. As such, metabolic modulation is a promising avenue for novel targets in cancer, immunology, and neurological disease. Learn how live-cell metabolic measurements generate critical… Read More
Drug development 2.0 – The partnership model in practice By Dr Brian Sheehan and Marco Cerato Over the last decade there has been a fundamental shift in the way in which drugs are developed and brought to market. Some years ago, the industry started to see profits falling… Read More
Cryo-EM accelerates drug discovery by delivering previously intractable structural insights By Hans Raaijmakers, et al. Cryo-electron microscopy (cryo-EM), a powerful biophysical technique that can analyse molecular assemblies, is changing the paradigm in structure-based drug design. As targets become more challenging, solving structures of drug target molecules… Read More
