Resources

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Case Study

Streamline preclinical drug discovery: PBMC-humanised mouse models

Discover a clinically predictive and reproducible platform developed by The Jackson Laboratory for simultaneous efficacy and safety assessment. This platform identifies patient-therapy combinations at risk of developing severe inflammatory syndrome, a potentially fatal complication. Optimise the safety profiles of your immunomodulatory therapeutics before first-in-human trials by leveraging this platform. In this bispecific case study, learn […]

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App Note

Fcγ Receptor and Antigen Kinetic Screening for Rapid Biosimilar Downstream Processing Assessment

Demonstrating similarity of biomolecules such as antibodies throughout upstream and downstream production processes is crucial. A rapid testing method is demonstrated using a Humira biosimilar (adalimumab) development sample, which assesses compatibility with three essential ligands in compliance with regulatory standards. This Application Note covers: How to rapidly assess column elution fractions of a biosimilar under […]

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App Note

Biologics developability: How Merck creates developability profiles for their mAbs

In this Application Note, discover how the Protein Sciences group at Merck & Co. builds developability profiles for their monoclonal antibody variants. Get an in-depth explanation of the experiments they set up to obtain parameters that help them decide which candidates have the best potential to reach the market, and how they validated that the data they […]

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Whitepaper

Bespoke biosafety: Building a custom biosafety cabinet

Simply having a biosafety cabinet (BSC) with large enough interior dimensions to house automation equipment is not always sufficient for ensuring proper airflow and adequate protection. In many cases, the equipment may actually interfere with the cabinet’s airflow, creating turbulence and rendering the cabinet ineffective. Download this whitepaper about customised biosafety cabinets for robotic equipment […]

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Feature Note

Sustainability in the Lab: A Step-by-Step Guide

Download this guide to gain insights on the steps you can take to achieve a more sustainable lab without compromising quality or performance. Learn about: Conducting an assessment Choosing the right equipment Conserving water and reducing waste Engaging and educating your team

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Whitepaper

Using patient-specific cells for disease modelling

Induced pluripotent stem cell (iPSC)-derived cells are a significant resource for disease modelling. They allow the use of cells directly from affected patients and have the potential to guide these cells towards multiple lineages. Download the whitepaper to: Explore iPSC-derived motor neuron morphology Discover how ALS disease phenotype is observed in microglia phagocytosis Understand whether […]

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Infographic

Four methods for thermal stability assessment of proteins

Thermal stability is among the most common critical quality attributes (CQAs) used for early developability assessment of biologics. In this infographic, learn about four methods for thermal stability assessment of proteins – what they measure, what the data tells you, and their benefits and limitations. While each provides unique value, the table will help you […]

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Case Study

Speeding up neuroscience research: Generating publishable data in 12 weeks

In this Case Study you will learn: How Professor Deepak Srivastava’s lab at King’s College London are working to unpick the complex biology of neuronal synapses to help us better understand neurological disorders like schizophrenia. How the researchers in Professor Srivastava’s lab have been able to generate publishable data on schizophrenia risk factors in just […]

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Guide

HuPK: A Humanised Platform for therapeutic antibody PK evaluation

Download the guide to learn more about:   How JAX’s HuPK™ Humanised FcRn Platform offers a validated and cost-effective solution for assessing the in vivo  preclinical pharmacokinetics and stability of Fc-based biologics and therapeutics carried by albumin.    JAX’s portfolio of FcRn humanised mouse models.   Study design templates, expected results, and troubleshooting tips for the most […]

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eBook

Assessing the efficacy of vaccines through laboratory assays

In the eighth eBook of the Hamilton series, ‘Assessing the Efficacy of Vaccines through Laboratory Assays’, we discuss: Vaccine development: Key milestones and impact of Covid-19 Laboratory tests commonly used to assess vaccines’ efficacy and the benefits of automating them Hamilton standardised and customised solutions for workflows such as qPCR, NGS, ELISA/ELISpot and virus-neutralisation assays

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Digital Article

A comprehensive approach to immunophenotyping for targeted drug discovery and development

With high costs of therapeutic development, success relies on optimising preclinical and early clinical studies. Download this content-rich digital article to read about considerations for implementing and standardising high-dimensional immune profiling methods into drug development programs. Learn about different applications that demonstrate the robustness and reproducibility of a mass cytometry-based analysis to deeply interrogate complex […]

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Whitepaper

Isomer FOMO? Unlock hidden isomers in your LC-MS analysis

MOBILion Systems is pioneering the evolution of separation science. High-resolution ion mobility (HRIM) on the MOBIE platform offers deeper, more accurate, and efficient characterisation of complex molecules than traditional methods. Download the whitepaper “High-Throughput Monitoring of Biotherapeutic Critical Quality Attributes with High-Resolution Ion Mobility-Mass Spectrometry (HRIM-MS)” to learn more about: Enhancing your analysis of post-translational […]

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Guide

Advanced flow cytometry handbook

Are you missing out on the easier way to do flow cytometry? In this new handbook, Sartorius introduces the value of advanced flow cytometry, so every scientist feels empowered to run an experiment and analyse the data with confidence. This easy-to-use digital guide includes an introduction to the iQue® Advanced Flow Cytometry Platform and multiplexed […]

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Guide

Streamline your drug development pathway

In pharmaceutical development, collaborating with multiple Contract Development and Manufacturing Organisations (CDMOs) and Contract Research Organisations (CROs) poses potential hurdles – from poor communication to delays, errors, and inconsistent feedback during the progression from preclinical to formulation optimisation and clinical trials. Download this SGS guide to discover: How to collaborate in the fast-paced world of […]

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Infographic

Stability assessment of biologics during early development workflows

During early development of biologics, there are a large number of attributes researchers evaluate, but some of the most common centre around stability – asking if a biologic is well-folded, active and pure in its buffer, and whether it remains that way over time. Biophysical characterisations are valuable for providing this information without using a […]

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App Note

Measurement of mitochondrial toxicity using primary hepatocytes

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. In this App […]

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