Researchers have developed a molecular switch that wakes lung cancer cells up from a protective dormant state so that they are more accessible for treatment. Tumour cells can lapse into a sleep-like state and thereby evade the destructive effect of cancer drugs. Read More
Chemify has unveiled its first Chemifarm—a fully automated chemistry facility regarded as the world’s most advanced laboratory for molecular design and synthesis. Situated in Glasgow’s Maryhill district, the site unites Chemify’s AI-driven molecular-design engine with industrial-scale robotic synthesis, compressing the journey from concept to compound and accelerating… Read More
Mogrify and the MRC Laboratory of Molecular Biology (LMB), a research laboratory dedicated to understanding important biological processes at the molecular level, have announced an exploratory research collaboration. The project aims to develop novel protein expression systems by leveraging recent advances in direct cell reprogramming to help improve the production… Read More
https://www.ddw-online.com/wp-content/uploads/2020/12/collage.mp4 Cells are constantly moving throughout our bodies, performing functions crucial to tissue development, immune responses and general wellbeing. This locomotion—an essential feature of biological processes, both normal and pathological—is guided by chemical cues long studied by scientists interested in cellular migration. But a team of physicists and… Read More
Researchers from the Universities of Melbourne, York, Warwick and Oxford have shed light on how encapsulated viruses like hepatitis B, dengue and SARS-CoV-2 hijack the protein manufacturing and distribution pathways in the cell. They have also identified a potential broad spectrum anti-viral drug target to stop them in their tracks. Read More
The emergence of SARS-CoV-2 virus and the disease it causes, COVID-19, have fuelled significant shifts in preclinical research across the globe. Amid the worldwide health emergency created by high infection rates, rapid transmission spread and relatively high mortality rates, researchers are under pressure to understand the disease’s pathogenesis, develop… Read More
By Ibis Sanchez-Serrano and Rathnam Chaguturu Mitigation of COVID-19 pandemic requires a combination of effective epidemiological policies and the discovery/development of powerful drugs against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes this disease. This article examines the major initiatives being explored at the… Read More
By Dr Karin Bottcher High content screening (HCS) has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of COVID-19 and beyond. With a focus on viral diseases, this article… Read More
By Dr Ross Macdonald Cell-based therapies are being widely recognised for their potential to treat a variety of medical conditions, but they face major obstacles toward commercialisation. Traditionally, they have been difficult and expensive to make in large quantities. Read More
The COVID-19 antiviral race: we’re all in this together By Uduak Grace Thomas In response to the COVID-19 pandemic, international scientists from academia and industry have pooled their expertise and resources to identify candidate compounds that inhibit the activity of the SARS-CoV-2 main protease, in order to develop… Read More
Stem Cell Differentiation By Dr Lilian Hook Stem cells are extraordinary cells, capable of both self-renewal and differentiation to mature somatic cells in vivo and in vitro (1,2). They have many features and advantages which could revolutionise drug development and healthcare applications. Read More
Phenotypic Drug Discovery With High Content Screening Sponsored by PerkinElmer Early drug discovery used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system – cells, tissue, or organisms – and asking the question, did this entity affect the phenotype?… Read More
Meet Stunner: The One-Shot Protein Concentration and Sizing Combo Sponsored by Unchained Labs Stunner pulls double-duty so you don’t have to. It’s the one and only system that combines high-speed UV/Vis spectral analysis and Dynamic Light Scattering (DLS) for quantifying concentration and nailing down protein stability. Read More
Targeting Energy Metabolism for Cancer Therapeutic Discovery using Agilent Seahorse XF Technology Sponsored by Agilent This white paper discusses targeting energy metabolism for cancer therapeutic discovery using Agilent Seahorse XF technology. Abstract Altered energy metabolism is now recognized as a driver… Read More
Enterprise Therapeutics publishes paper on novel therapeutic approach for treatment of all cystic fibrosis patients. Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of patients suffering with respiratory disease, today announced the publication of… Read More
Image: Joshua Coleman According to the Department of Health and Social Care (DHSC), pharmaceutical companies should stockpile six weeks’ worth of goods “to help ensure the continuity of supply of medical goods into and out of the UK”. In a letter to the industry Steve Oldfield, Chief Commercial Officer,… Read More
