Cancer Research

Scientist in laboratory

Precision medicine study could find new options for rare cancers

25 November 2022

Cancer Research UK, The University of Manchester and Roche have opened a multi-drug, precision medicine trial for people with rare cancers.  The trial is set up to recruit both paediatric and adult patients with any rare cancer type and is one of very few precision medicine platform trials in the world targeting these populations.  The […]

X-ray showing colon cancer

Bowel cancer protein study could lead to less toxic cancer drugs

25 November 2022

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.  Using Nobel Prize-winning microscopy techniques, the researchers revealed how the tankyrase protein switches itself on and off by self-assembling into 3D chain-like structures.  Their study, […]

Cancer research lab

Academic-industry collaboration extends cancer drug alliance 

22 November 2022

Cancer Research UK’s innovation engine, Cancer Research Horizons, and Newcastle University, have agreed an extension of their strategic drug discovery alliance with Astex Pharmaceuticals.  The alliance will continue to focus on the discovery of potential new cancer drugs with associated biomarkers, with the aim of providing an innovative route to the development of more effective […]

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Scientists will target cancer’s ecosystems under new strategy

22 November 2022

Cancer is supported by complex ecosystems within the body which can be disrupted by cutting-edge new treatments and cures, cancer researchers have concluded.  The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust have revealed plans to direct research against the cells, signals and immune response in the tissue environment that nurtures […]

Bone marrow organoids

‘Bone marrow in a dish’ used to study personalised cancer drugs

17 November 2022

Scientists from Oxford University and the University of Birmingham have made the first bone marrow ‘organoids’ that include all the key components of human marrow.   The technology allows for the screening of multiple anti-cancer drugs at the same time, as well as testing personalised treatments for individual cancer patients.    The study, published in the journal […]

Neurons

Electrical network between cancer cells may lead to new treatments

17 November 2022

New research has found variable voltages in the membranes of breast cancer cells, revealing clues about how they grow and spread. The study, led by Imperial College London and The Institute of Cancer Research, London, could help us better understand how cancer cells ‘decide’ when to multiply and where to spread to. When cells become […]

T cells attacking cancer

Positive interim data for cell therapy in solid tumours

16 November 2022

Triumvira Immunologics has revealed positive clinical data from its ongoing TACTIC‑2 Phase I/II trial of TAC01-HER2 in patients with human epidermal growth factor receptor 2 (HER2) positive solid tumours.  These interim data demonstrate that TAC01-HER2 is well-tolerated and clinical activity was observed in the two higher dosing cohorts, with a 67% disease control rate in cohort […]

Monoclonal antibodies

Phase I trial of lead antibody candidate launched

15 November 2022

DynamiCure has dosed the first patients in its Phase I clinical trial evaluating the first of the company’s two anti-CD93 monoclonal antibody candidates, DCBY02, in adults with a wide range of advanced cancers.  CD93 is a novel target downstream of VEGF-A (vascular endothelial growth factor) that has been shown to play a critical role in […]

T cells attacking cancer

Experimental cancer vaccine shows promise in animal studies 

15 November 2022

An experimental therapeutic cancer vaccine induced immune system responses that led to significant tumour regression in mice, according to investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.    The researchers found that intravenous (IV) administration of the vaccine SNAPvax boosted the number of cytotoxic T cells […]

Copper-binding proteins

Copper-binding proteins are potential new cancer drug targets 

14 November 2022

New research about how cancer-related proteins bind copper ions opens up potential new drug targets to treat cancer.   Studies have shown that the level of copper in tumour cells and blood serum from cancer patients is elevated, and the conclusion is that cancer cells need more copper than healthy cells. Higher levels of copper also […]

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