Cancer Research

US biotech start-up set to have huge impact on breast cancer treatment landscape

28 September 2020 , By Lu Rahman

Backed by more than 20 years of research and development expertise, Concarlo Holdings is developing diagnostics and therapeutics that could have huge impact for metastatic breast cancer patients. Lu Rahman finds out more. Stacy Blain, Co-Founder, Concarlo Holdings, wants to change the conversation around breast cancer. This biotechnology start-up whose technologies aim to diagnose and […]

Flipping a metabolic switch to slow tumour growth

14 August 2020 , By Christian Metallo

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive ‘switch’ that decreases tumour growth. This is according to a new study by a team of San Diego scientists, who published their findings in the journal Nature. By restricting the dietary amino acids serine and glycine, or pharmacologically targeting the serine synthesis enzyme phosphoglycerate dehydrogenase, […]

Pre-existing immune-resistant cancer cells identified in melanoma

10 August 2020 , by Daniel Peeper

Researchers at the Netherlands Cancer Institute have discovered a cluster of tumour cells that are refractory to immunotherapy and that exists even prior to treatment. This finding, which was published in the scientific journal Nature Communications, may lead to new therapies that eliminate cancer more effectively. The research group, led by Daniel Peeper, focused on melanoma, […]

Orphan Drug Designation granted to tinostamustine for rare form of leukaemia

7 August 2020 , By Brian Sheehan

Tinostamustine is in early phase clinical trials (Phase I) to investigate its use as a potential future treatment option in this area of significant unmet patient need. Mundipharma has revealed  that the European Commission (EC) has adopted the European Medicines Agency (EMA) Committee for Orphan Medicinal Products recommendation to grant Orphan Drug Designation (ODD) to tinostamustine, […]

Researchers discover cell communication mechanism that drives cancer adaptation

5 August 2020 , By Professor Deborah Goberdhan, Professor Clive Wilson and Professor Adrian Harris

Collaborative Cancer Research UK-funded studies from University of Oxford researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies. This mechanism involves cells releasing small vesicles, known as exosomes. These contain complex mixtures of proteins, RNAs and other molecules, which can re-programme […]

Cancer Research UK, University of Southampton and Touchlight Genetics develop head and neck cancer vaccine

5 August 2020 , DDW editorial

This a new clinical development partnership to progress a therapeutic DNA vaccine, TGL-100, into an early phase clinical trial targeting head and neck squamous cell carcinoma (HNSCC) HNSCC is the UK’s eighth most common cancer, but treatment options are limited and around 4,000 of those affected in the UK die each year. Whilst existing immunotherapies […]

Drug target for aggressive breast cancer found

5 August 2020 , by Dr Bruno Simões and Professor Rob Clarke

A team of British and American scientists has discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of […]

Collaboration to investigate IMM-101 in difficult to treat cancers

3 August 2020 , DDW editorial

This will explore clinical trials with IMM-101, in combination with other treatments, in difficult to treat cancers, with a particular focus on epithelial cancers such as pancreatic cancer and sarcoma. Immodulon, an immuno-oncology company, and the Champalimaud Foundation, a private, non-profit, research organisation in Lisbon, Portugal, have announced research intended to examine the potential use […]

Merging two immunotherapies may be more effective treatment against some cancers

29 July 2020 , by Julia Evangelou Strait

Some of the most promising advances in cancer treatment have centred on immunotherapies that rev up a patient’s immune system to attack cancer. However, immunotherapies don’t work in all patients, and researchers have been searching for ways to increase their effectiveness. Now, researchers at Washington University School of Medicine in St. Louis have combined two immunotherapy strategies […]

Researchers ID new target in drive to improve immunotherapy for head and neck cancer

29 July 2020 , By Dr. Cun-Yu Wang

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer. A study in mice found that using an anti-PD1 immunotherapy drug in combination with PTC209, an inhibitor […]

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