Cancer Research

What it takes to make cancer research more inclusive

16 August 2022

The drug discovery sector is working to address cancer disparities. Anita Ramanathan examines the importance of inclusivity and diversity throughout the drug discovery and development process.  While the risk of cancer is universal, some groups are disproportionately affected by cancer compared to others. Disparities resulting from genetic, environmental, social, and economic factors increase cancer risks […]

EMA approves early-stage breast cancer treatment  

16 August 2022

A precision medicine for early-stage breast cancer has been approved by the European Medicines Agency (EMA).   Developed by AstraZeneca and Merck & Co (MSD) under the brand name Lynparza, the treatment is a precision medicine which blocks DNA damage response (DDR) in cells or tumours that have a deficiency in homologous recombination repair (HRR), such […]

Improving quality control for CAR T cell therapies

10 August 2022

By Mark White, Associate Director of Biopharma Product Marketing at Bio-Rad and Marwan Alsarraj, Biopharma Segment Manager, Digital Biology Group. Until about 25 years ago, the best treatment option for someone with blood cancer was either toxic radiation and chemotherapy or a bone marrow transplant that posed additional life-threatening risks to the patient1. But decades […]

Scientists discover how melanoma invades new tissue  

9 August 2022

Scientists have discovered how melanoma skin cancer cells invade new tissues in research they hope might lead to new treatments.  A team from The Institute of Cancer Research, London discovered that melanoma cells harness a gene usually used by growing nerves to escape from their immediate area and invade new tissues.   They found that melanoma […]

Could elephant genes hold the key to avoiding cancers?

29 July 2022

Scientists modelling the cancer-suppressing p53 gene identify how the 20 different molecules unique to elephants get activated for increased sensitivity and response against carcinogenic conditions – with implications for cancer treatments in humans. Scientists from seven research institutions including the University of Oxford and the University of Edinburgh have used pioneering bioinformatic modelling to investigate […]

Mathematical modelling can explain immunotherapy responses

27 July 2022

The size of tumour and immune cell populations and their interactions over time impact outcomes to treatment. Immunotherapies that activate the immune system to seek and kill cancer cells have greatly improved outcomes for many patients with solid tumours. There is still, however, a subset of patients who do not see benefit from this type […]

eBook: Insight into the latest oncology innovation

6 May 2022

This 26-page DDW eBook, sponsored by The Jackson Laboratory, contains exclusive insight from industry experts on: How machine learning is currently used across different stages of cancer research Accelerating research: the path forward for treating rare cancers Immunotherapy challenges and the tools for research Why combination immunotherapies are one of the most exciting ATMPs being […]

Merck & Pfizer’s bladder cancer drug gets NICE approval  

12 April 2022

The National Institute for Health and Care Excellence (NICE) has overturned a previous decision where it chose not to recommend the immunotherapy BAVENCIO (avelumab) for the treatment of bladder cancer.  The decision comes after avelumab’s developers, Merck KGaA and Pfizer, appealed the prior Final Appraisal Document (FAD) by NICE. Avelumab is now recommended as a maintenance […]

This week in DDW – oncology focus

8 April 2022

DDW Deputy Editor Reece Armstrong takes a look at some of the biggest developments that took place within oncology this week (4 April – 8 April).  Scientists win award for transforming breast cancer treatment  A team of scientists from The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust has won a […]

Redx collaborates with Garvan on cancer project  

7 April 2022

Biotechnology company RedX is collaborating with the Garvan Institute of Medical Research on a project investigating novel therapeutic targets in cancer-associated fibrosis.  The collaboration aims to better understand treatments that could lead to increased patient survival in currently very poorly treated highly fibrotic cancers, such as pancreatic cancer.   Redx and Garvan will work on developing […]

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