Cancer Research

Lipidomics in biomedical research: chance and challenges

9 August 2021

Lipids are essential for numerous functions in the human body. They are not only components of cell membranes, extracellular vesicles and hormones, but also store energy, facilitate metabolism, mediate cell signalling pathways, and much more. This incredibly diverse class of molecules encompasses at least 100,000 distinct species in humans.1 Due to their great complexity and […]

The personal touch: the scientist making an impact in cancer research

6 August 2021

At 33, Martyn Hiscox is an inspiration to scientists in oncology research. Principal scientist with Adaptimmune, a UK cell therapy biotech, Lu Rahman uncovers Hiscox’s passion, dedication and the personal reason for developing cell therapy treatments for cancer. Hiscox clearly has immense respect for Adaptimmune – its innovation and its focus on designing and delivering […]

Unlocking the microbiome as a target for drug discovery using C. elegans

5 August 2021

David Weinkove, CEO Magnitude Biosciences, examines the untapped microbiome and its potential into helping unlock new therapies. Why the microbiome? The human microbiome is an important emerging field for drug discovery that harbours an array of life-changing medicines for patients. Whilst it is increasingly acknowledged that the human microbiome holds great promise for healthcare, its […]

Appointment strengthens the experience of RareCan

4 August 2021

RareCan, a new company accelerating research into rare cancers, has appointed Dr Anita Cooper as Non-Executive Director. The appointment is said to strengthen the scientific and pharmaceutical experience of RareCan’s board in support of the company’s planned commercial growth. With over 30 years’ global business experience, Cooper has worked across diverse functions, skill levels and […]

Cancer project enters Immuno-oncology Alliance

30 July 2021

In the UK, researchers Professor Andrew Beggs and Professor Gary Middleton from the Institute of Immunology and Immunotherapy and the Institute of Cancer and Genomic Sciences have partnered with Cancer Research UK in a target identification project for the Immuno-oncology Alliance, which translates discovery science into new therapeutics for cancer patients. The Immuno-oncology Alliance, formed […]

Researchers develop novel therapy that could be effective in many cancers

26 July 2021

Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery. The therapy is an engineered molecule called MS21 that causes the degradation of AKT, an enzyme that is overly active in many cancers. This […]

First patient dosed with Gadeta’s gamma delta TCR cell therapy

14 July 2021

Gadeta, a clinical-stage company developing gamma delta (γδ) T-cell receptor (TCR)-based immunotherapies for cancer patients, has announced the dosing of the first patient with GDT-002 (formerly labelled TEG002), a potential first-in-class cellular immunotherapy for the treatment of cancer. The multicentre Phase I/II study in collaboration with the Dana-Farber Cancer Institute, Mass General Brigham Cancer Care […]

Biotech’s pursuit of next-generation CAR-T

12 July 2021

Pierre-Louis Joffrin leads Corporate Development at Mogrify. He examines immunotherapies including an assessment of the next generation of stem cell derived products. Biotech has joined the pursuit of next-generation CAR-Ts and it’s not subtle. Some new, others having pivoted towards the area, there are now over 100 companies working on CAR-Ts or derivatives around the […]

Research collaboration will develop bispecific agents for oncology

5 July 2021

Ixaka and SomaLogic have created a research collaboration to support the development of aptamer-based bispecific therapeutics. The collaboration will evaluate the safety and efficacy of antigen-specific SOMAmer reagents (modified aptamers that bind tightly and specifically to protein targets) previously identified and screened by SomaLogic as potential candidates for combination with Ixaka’s anti-CD3 aptamers. Ixaka is […]

Immune checkpoint inhibitors: What are the risks?

1 July 2021

Immuno-oncology has advanced greatly through T cell-based therapeutic approaches (particularly immune checkpoint inhibitors). However, immune checkpoint inhibitors (ICIs) aren’t efficacious in all patients, and they carry risks. What are these risks? Courtney Ferrebee, PhD, Field Applications Scientist, Taconic Biosciences speaks to Lu Rahman. Preclinical in vivo models serve as important tools for studying the mechanisms […]

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