Mass spectrometry / NMR

Sensitive signature peptide quantification using accurate mass spectrometry is a free webinar that was hosted by DDW on December 1, 2021, at 4PM GMT, 9AM PT; 12PM ET; 5PM CET. It was supported by SCIEX.  Dr. Xin Zhang, Senior Application Scientist at SCIEX, presented an assay development method using accurate mass spectrometry to quantify a […]

OMass Therapeutics has shared its pipeline of five novel, differentiated small molecule drug programmes, targeting intractable or inadequately drugged membrane and complex-bound protein targets such as GPCRs (G-protein-coupled receptors), solute carriers and intracellular protein complexes.  The company’s selected programmes focus on validated targets in immunology & rare disease indications with high unmet need. The programmes include:  MC2 (melanocortin-2), a GPCR that binds to […]

A free webinar, Sensitive signature peptide quantification using accurate mass spectrometry, was hosted by DDW on December 1, 2021, at 4PM GMT, 9AM PT; 12PM ET; 5PM CET. It was supported by SCIEX.   Emerging advancements in protein biotherapeutics are driving the need for more sensitive and accurate bioanalytical methods for their quantification. Serving as an orthogonal technology to […]

PreOmics, developer of tools for mass spectrometry-based protein analyses, has launched BeatBox, its new sample preparation tool for tissues and cells. BeatBox delivers tissue homogenisation and can process up to 96 tissue samples in 10 minutes from 1-5 mg of tissue, with no cross-contamination.    According to the company, BeatBox was shown to provide higher extraction of […]

The importance of biotherapeutics as a class of drugs continues to increase. Indeed, their low toxicity and high specificity justify their investigation as drug candidates. Yet, quantification studies of biotherapies in complex biological matrices can be very challenging. In particular, high background noise and interferences due to endogenous proteins may compromise the assay. Dr. Xin Zhang, […]

MOBILion Systems will showcase its first commercial High-Resolution Ion Mobility (HRIM) product, MOBIE, at the 69th Annual American Society for Mass Spectrometry (ASMS) conference.   Taking place from October 31 to November 4, the conference is the first in-person ASMS since 2019 and is being held in Philadelphia.  The recently launched MOBIE addresses characterisation challenges faced during biopharmaceutical drug development […]

Waters Corporation and Sartorius have partnered to provide bioprocess experts with direct access to high-quality mass spectrometry (MS) data to accelerate the speed and improve the accuracy of biopharmaceutical process development.   The partnership will implement the BioAccord LC-MS System from Waters as a new bioprocess analyser with data connectivity to Sartorius’ Ambr multi-parallel bioreactor systems to deliver mass spectral […]

News round-up by DDW’s Megan Thomas for 6 – 10 September  DDW’s Megan Thomas selects five stories which showcase results, data, partnerships and research which offer a promising future for both drug development and eventual treatment of a number of diseases.   New potential therapy for schizophrenia patients  Newron Pharmaceuticals has initiated Study 008A, the first potentially […]

According to Thermo Fisher Scientific, lab managers, technology leaders and principal scientists in pharmaceutical, food and environmental laboratories can use its new mass specrometry (MS) portfolio and chromatography solutions to accelerate throughput and improve sensitivity to meet rapidly changing regulatory requirements and the fast responses needed to tackle emerging human and environmental health risks.  The Thermo Scientific […]

908 Devices has announced two data analysis partnerships to integrate with the REBEL, its first at-line fresh and spent cell media analyser for bioprocess labs. With the integration of leading data exploratory tool Sartorius’ SIMCA and Securecell’s Lucullus Process Information Management System (PIMS), users can turn REBEL data into deeper actionable insights to drive operational […]

MOBILion is advancing separation science with the commercialisation of High-Resolution Ion Mobility Mass Spectrometry (HRIM-MS) based on Structures for Lossless Ion Manipulation (SLIM). This product addresses characterisation challenges faced during biopharmaceutical drug development and quality monitoring. MOBIE provides resolution and reproducibility, faster, simpler method development, and greater instrument uptime. This new technology will help accelerate […]

Kim Ekroos PhD, Founder & CEO Lipidomics Consulting and Kelly Moser PhD, Lab Operations Manager and Applications Scientist, MOBILion Systems examine advancements in research of biomarkers for early diagnostics and effective treatments for neurodegenerative disorders with High-Resolution Ion Mobility Mass Spectrometry Although the first descriptions and classifications of lipids appeared almost two centuries ago, it […]

By Professor Yasushi Ishihama, Laboratory of Molecular and Cellular BioAnalysis, Kyoto University Mass spectrometry (MS) is now widely used in protein biochemistry and proteomics to identify and characterise proteins, with technology constantly evolving to achieve higher depths of coverage, speed, and sensitivity. For example, tandem mass spectrometry (MS/MS) is a sensitive, accurate, and efficient method […]

Andreas Huhmer, Senior Director, Proteomics and Metabolomics, Thermo Fisher Scientific, examines the mass spectrometry techniques providing detailed insight into virus structure and function Our ability to quickly and accurately understand new viruses has been significantly tested in 2020, with the emergence of SARS-CoV-2, the coronavirus causing the COVID-19 pandemic. Since the first reports of an […]

The COVID-19 antiviral race: we’re all in this together By Uduak Grace Thomas In response to the COVID-19 pandemic, international scientists from academia and industry have pooled their expertise and resources to identify candidate compounds that inhibit the activity of the SARS-CoV-2 main protease, in order to develop a clinically effective antiviral. The aptly named […]

Thermo Scientific iCAP PRO Series ICP-OES instruments capture a complete spectrum in a single measurement for high matrix samples. Scientists no longer need to limit routine trace element analysis workflow productivity with the launch of a new series of inductively coupled plasma optical emission spectroscopy (ICP-OES) instruments for food and beverage, consumer safety, industrial, environmental […]