Mass spectrometry / NMR

Arndt Asperger, Senior Applications Scientist, Bruker Daltonics and Meike Hamester, Vice President Label-Free Technologies, Bruker Daltonics, examine how challenges in mass spectrometry for high-throughput screening can be overcome using a label-free approach.   Mass spectrometry is inherently appealing for high-throughput screening (HTS), because it avoids certain drawbacks of label-based assays, but long-standing limitations of cost per sample, […]

Download the new App Note from Analytik Jena to find out more about: The detection of lipid changes in microglia cells in generating therapeutic approach towards neuroinflammation diseases The application of label-free matrix-assisted laser desorption/ionisation (MALDI) MS cell fingerprinting workflows or cellular assays capable of characterising drug off-target responses with high throughput sample preparation done […]

By Idlir Liko, Kleitos Sokratous & Miguel Silva at OMass Therapeutics Current drug discovery methods have limited success against certain drug targets and better approaches are needed. Professor Dame Carol Robinson’s work, including her recent publication in Nature, highlights how native mass spectrometry offers a new way to discover therapeutics against inadequately drugged or intractable […]

In this article, Professor Zheng-Zhu (Principal Investigator and Director of Metabolomics Research Center at the Shanghai Institute of Organic Chemistry) and Lucy Woods (Business Unit Manager for Phenomics and Metabolomics at Bruker Daltonics), summarise the most important configurations and options for partnering IMS–MS with liquid chromatography (LC) and show how this approach could revolutionise metabolome […]

In this article, Komal Kedia (Senior Scientist at Merck), Rena Zhang (Senior Scientist at Merck), Weixun Wang (Senior Scientist at Merck), Kevin Bateman (Scientific Associate VP at Merck) and Kelly Moser (Applications Manager at MOBILion Systems) show how ganglioside isomers with suspected roles in neurodegenerative diseases can be separated on the basis of their ion […]

Dr. Zack Gurard-Levin, Chief Scientific Officer, SAMDI Tech, breaks down three critical components to consider to ensure a successful affinity selection mass spectrometry (ASMS) drug discovery programme.  The ability to rapidly identify small molecules that non-covalently bind to a specific target is a critical tool that will benefit many promising therapeutic targets. In drug discovery, binding […]

A free webinar, Sensitive signature peptide quantification using accurate mass spectrometry, was hosted by DDW on December 1, 2021, at 4PM GMT, 9AM PT; 12PM ET; 5PM CET. It was supported by SCIEX.   Emerging advancements in protein biotherapeutics are driving the need for more sensitive and accurate bioanalytical methods for their quantification. Serving as an orthogonal technology to […]

The importance of biotherapeutics as a class of drugs continues to increase. Indeed, their low toxicity and high specificity justify their investigation as drug candidates. Yet, quantification studies of biotherapies in complex biological matrices can be very challenging. In particular, high background noise and interferences due to endogenous proteins may compromise the assay. Dr. Xin Zhang, […]

Sensitive signature peptide quantification using accurate mass spectrometry is a free webinar that was hosted by DDW on December 1, 2021, at 4PM GMT, 9AM PT; 12PM ET; 5PM CET. It was supported by SCIEX.  Dr. Xin Zhang, Senior Application Scientist at SCIEX, presented an assay development method using accurate mass spectrometry to quantify a […]

OMass Therapeutics has shared its pipeline of five novel, differentiated small molecule drug programmes, targeting intractable or inadequately drugged membrane and complex-bound protein targets such as GPCRs (G-protein-coupled receptors), solute carriers and intracellular protein complexes.  The company’s selected programmes focus on validated targets in immunology & rare disease indications with high unmet need. The programmes include:  MC2 (melanocortin-2), a GPCR that binds to […]