Lead discovery

#Business #Gene editing #High throughput screening #Lead discovery #RNA #Screening

Horizon Discovery streamline CRISPR gene editing workflows

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation technologies, today announced the addition of predesigned synthetic single guide RNA (sgRNA) to its product range. The sgRNAs, available individually or as library collections, expand the Company’s Edit-R gene engineering… Read More

#News

#Cell therapy #Drug development #Drug discovery #Drug targets #Gene therapy #Lead discovery #Oncology #RNA #Stem cells #System biology #Therapeutics

Grey Wolf completes financing to accelerate development of ERAP2 therapies

Grey Wolf Therapeutics completes £2.5 million ($3.3 million) Series A2 financing to accelerate development of therapies targeting ERAP2. Grey Wolf targets ERAP antigen presentation pathways with the aim of ‘illuminating’ non-responsive tumors for attack and destruction by the immune system. Grey Wolf Therapeutics, a drug discovery… Read More

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#Biochemistry #Cell therapy #Cellular & Molecular biology #Chemistry #Clinical specialities #Drug development #Drug discovery #Gene therapy #Lead discovery #RNA #Therapeutics

Enterprise Therapeutics publishes paper on novel cystic fibrosis approach

Enterprise Therapeutics publishes paper on novel therapeutic approach for treatment of all cystic fibrosis patients. Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of patients suffering with respiratory disease, today announced the publication of… Read More

#News

#Academic #Analysis #Assay development optimisation & technology #Cellular assays #Drug development #Drug discovery #Lead discovery #Lead optimisation #Preclinical #RNA #Screening #Target validation #Toxicology

Arctoris Ltd Successfully Moves into its New Global Headquarters in Oxford, UK

State-of-the art facility is home to the company’s next-generation, fully automated platform for drug discovery. Arctoris Ltd, the developer of the world’s first fully automated drug discovery platform, today opened the doors to its new global headquarters and state-of-the-art research and development (R&D) facility in Oxford,… Read More

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#Analysis #Business #Lead discovery #Mass spectrometry / NMR #Metabolomics #Protein chemistry / Proteomics #RNA #Therapeutics

Thermo Fisher to showcase new products at Virtual ASMS Event

Thermo Fisher Scientific will provide online programming and virtual exhibits to introduce scientists to a number of new products that build on its leading Orbitrap platform and expand research applications. The company said it will showcase its newest instruments, software and workflow solutions during a company-hosted virtual event, vLC-MS.com,… Read More

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#AI / data analytics / healthtech / informatics #Analysis #Assay development optimisation & technology #Automation / robotics #Cell therapy #Drug development #Drug discovery #Gene therapy #Immunology #Lead discovery #Oncology #Pathology #Precision medicine #RNA #Screening #Stem cells #Therapeutics

Researchers discover cell communication mechanism that drives cancer adaptation

Collaborative Cancer Research UK-funded studies from University of Oxford researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies. This mechanism involves cells releasing small vesicles, known as exosomes. These contain complex mixtures of proteins,… Read More

#Cancer Research #Covid-19 #News

#Business #Drug development #Drug discovery #High Content Screening #Immunology #Immunology / Virology & Vaccines #Lead discovery #Oncology #Preclinical #Regulatory #Stem cells

Cancer Research UK collaborate to develop head and neck cancer vaccine

This a new clinical development partnership to progress a therapeutic DNA vaccine, TGL-100, into an early phase clinical trial targeting head and neck squamous cell carcinoma (HNSCC) HNSCC is the UK’s eighth most common cancer, but treatment options are limited and around 4,000 of those affected in the… Read More

#Cancer Research #News

#Academic #Business #Cell therapy #Cellular assays #Clinical specialities #Drug development #Drug discovery #Enabling technologies #Genomics #High Content Screening #High throughput screening #Imaging #Lead discovery #Microfluidics #Screening #Stem cells #Target validation #Therapeutics #Translational #Translational chemistry

Drug target for aggressive breast cancer found

A team of British and American scientists has discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously… Read More

#Cancer Research #News

#Biologics / Biotechnology #Clinical trials #Drug development #Drug discovery #Gene therapy #Immunology / Virology & Vaccines #Lead discovery #Regulatory #RNA

Phase III clinical trial of investigational vaccine for COVID-19 begins in US

Multi-site trial to test candidate developed by Moderna and NIH. A Phase III clinical trial designed to evaluate if an investigational vaccine can prevent symptomatic coronavirus disease 2019 (COVID-19) in adults has begun. The vaccine, known as mRNA-1273, was co-developed by the Cambridge, Massachusetts-based biotechnology company Moderna and… Read More

#Covid-19 #News

#Business #Clinical trials #Drug development #Drug discovery #Imaging #Immunology / Virology & Vaccines #Lead discovery #Regulatory #RNA

GSK and Sanofi to supply US government with 100 million doses of COVID-19 vaccine

Sanofi and GSK have announced a collaborative effort with the US government to accelerate the development and manufacturing of a COVID-19 recombinant protein-based vaccine. The vaccine candidate, developed by Sanofi in partnership with GSK, is based on the recombinant protein-based technology used by Sanofi to produce an influenza… Read More

#Covid-19 #News

#Drug development #Drug discovery #Imaging #Lead discovery #QA/QC #RNA #Screening

NanoImaging Services opens West Coast facility to help grow of its CryoEM network

NanoImaging Services, has opened a new facility close to its San Diego headquarters. The new data collection centre will be the largest private facility for cryoEM data collection globally, says the company, and will serve both national and international clients. Designed to be a data collection farm, this… Read More

#News

#Analysis #Drug development #Drug discovery #Drug targets #Lead discovery #Regulatory #RNA

Analysis could find drug targets for attention deficits and sensory hypersensitivity

Image: Jesse Orrico Many people with autism experience sensory hypersensitivity, attention deficits and sleep disruption. One brain region implicated is the thalamic reticular nucleus (TRN), which is believed to act as a gatekeeper for sensory information flowing to the cortex, by Anne Trafton, MIT News Office A team… Read More

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#Academic #Assay development optimisation & technology #Business #Cell therapy #Cellular assays #Chemical engineering #Clinical trials #Drug development #Drug discovery #Enabling technologies #Gene editing #Gene therapy #Genomics #High Content Screening #High throughput screening #Imaging #Lead discovery #Microfluidics #Oncology #RNA #Screening #Stem cells #Therapeutics #Toxicology #Translational #Translational chemistry

Merging two immunotherapies may be more effective treatment against some cancers

Some of the most promising advances in cancer treatment have centred on immunotherapies that rev up a patient’s immune system to attack cancer. However, immunotherapies don’t work in all patients, and researchers have been searching for ways to increase their effectiveness. Now, researchers at Washington University School of… Read More

#Cancer Research #News

#Cell therapy #Drug development #Drug discovery #Drug targets #Gene therapy #Lead discovery #Oncology #Preclinical #RNA #Stem cells

Researchers ID new target in drive to improve immunotherapy for head and neck cancer

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer. A study in mice found that using an anti-PD1 immunotherapy… Read More

#Cancer Research #News

#Academic #Assay development optimisation & technology #Business #Cellular assays #Drug development #Drug discovery #Enabling technologies #Gene editing #Genomics #High Content Screening #High throughput screening #Imaging #Lead discovery #Microfluidics #Precision medicine #Preclinical #Screening #Stem cells #Therapeutics #Translational #Translational chemistry

British Patient Capital invests in life-changing biotech companies

British Patient Capital is committing $65m to SV Health Investors’ latest fund, SV7 Impact Medicine Fund (IMF), to turn scientific breakthroughs into biotech companies producing high impact precision medicine drugs for poorly treated diseases. The commitment increases British Patient Capital’s exposure to life sciences and health technology, building… Read More

#Covid-19 #News

#Genomics #Lead discovery #Precision medicine #Protein chemistry / Proteomics

Biopharma R&D interest in quantum computing due to efficiency and effectiveness benefits

27 July 2020 Image: Michael Dziedzic New survey results from the Pistoia Alliance, the Quantum Economic Development Consortium (QED-C) and QuPharm show almost one third of life science organisations polled are set to begin quantum computing evaluation this year. A further 39% are planning to evaluate next year… Read More

#News