Lead discovery

#Academic #Biochemistry #Biomarkers #Cellular & Molecular biology #Clinical trials #Drug discovery #Drug targets #Genetics / genomes #Lead discovery #Molecular medicine #RNA #Therapeutics

New drug could treat blood cancer and solid tumours

13 July 2020 Image: National Cancer Institute Scientists have revealed details of the discovery of a new cancer drug that could be used to treat a range of cancer types, including some blood cancers and solid tumours. The drug, fadraciclib, was jointly discovered by scientists at The Institute… Read More

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#Biologics / Biotechnology #Cell therapy #Clinical trials #Drug development #Drug discovery #Drug targets #Immunology #Immunology / Virology & Vaccines #Lead discovery #Oncology #Precision medicine #Preclinical #RNA #Therapeutics #Translational #Translational chemistry

Cancer vaccine shows promising signs

The Translational Research Institute-based Mater researchers in partnership with The University of Queensland have developed a new cancer vaccine, which has shown promising signs in preclinical laboratory studies. Funded by grants from the Worldwide Cancer Research in the United Kingdom, and Mater Foundation, the new vaccine could be potentially… Read More

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#AI / data analytics / healthtech / informatics #Analysis #Business #Drug development #Drug discovery #Imaging #Lead discovery #RNA #Screening #Therapeutics

Nanoimaging Services expands with East Coast facility

8 July 2020 Image: Osman Rana NanoImaging Services (NIS), has opened a facility in Boston. NIS is expanding with services and locations to support its growing customer base requiring cryoEM for drug discovery and vaccine development applications. “For more than a decade, we’ve applied our scientific leadership and… Read More

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#Academic #AI / data analytics / healthtech / informatics #Analysis #Biochemistry #Business #Cell culture #Chemistry #Computational chemistry #Drug development #Drug discovery #Enabling technologies #Lead discovery #Lead optimisation #Medicinal chemistry #System biology

How drug discovery software is inspiring US high-school students

Optibrium and the North Carolina School of Science and Mathematics (NCSSM), are celebrating five years of an education support collaboration. As part of this specialist science and technology summer school initiative, Optibrium provides free access to StarDrop, Optibrium’s software for small molecule design, optimisation and data analysis. This… Read More

#Covid-19 #News

#Academic #Assay development optimisation & technology #Business #Cellular & Molecular biology #Cellular assays #Chemical engineering #Drug development #Drug discovery #Enabling technologies #Gene editing #Genomics #High Content Screening #High throughput screening #Imaging #Immunology #Lead discovery #Microfluidics #Molecular medicine #RNA #Screening #Stem cells #Therapeutics #Translational #Translational chemistry

Cell ‘membrane on a chip’ could speed up screening of drug candidates for COVID-19

Researchers have developed a human cell ‘membrane on a chip’ that allows continuous monitoring of how drugs and infectious agents interact with our cells. It may soon be used to test potential drug candidates for COVID-19. The researchers, from the University of Cambridge, Cornell University and Stanford University,… Read More

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#Clinical specialities #Clinical trials #Drug discovery #Imaging #Lead discovery #Regulatory

Abivax treats first patient in COVID-19 clinical trial in France

The first patient has been treated in Abivax’s Phase IIa/III study of ABX464 in COVID-19 patients at the University Hospital Centre in Nice, France. The randomised, double-blind, placebo-controlled miR-AGE study investigates the effect of early treatment (at point of diagnosis) in 1,034 COVID-19 elderly or high-risk patients. The… Read More

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#Biologics / Biotechnology #Cell therapy #Clinical specialities #Clinical trials #Drug discovery #Gene therapy #Imaging #Lead discovery #Precision medicine #RNA

Clinical trial examines alpha-1-antitrypsin for severe COVID-19 infection

Clinician scientists at RCSI University of Medicine and Health Sciences, Ireland, have begun a clinical trial of a promising therapy for critically ill COVID-19 patients in intensive care. In a paper published in the American Journal of Respiratory and Critical Care Medicine, the team, led by RCSI Professors… Read More

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#Academic #Analysis #Assay development optimisation & technology #Business #Cellular assays #Clinical specialities #Drug development #Drug discovery #Enabling technologies #Genomics #High Content Screening #High throughput screening #Imaging #Immunology #Lead discovery #Microfluidics #RNA #Screening #Stem cells #Therapeutics #Translational #Translational chemistry

MMR vaccination might protect children from COVID-19

Image: CDC A group of Lithuanian and Kurdish scientists have raised a hypothesis that the measles, mumps, and rubella (MMR) vaccine could protect children from COVID-19. The hypothesis is based on the discovered sequence similarity of the 30 amino acid residues between glycoproteins of SARS-CoV-2, measles and rubella… Read More

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#Academic #AI / data analytics / healthtech / informatics #Assay development optimisation & technology #Business #Cellular assays #Clinical specialities #Drug development #Drug discovery #Enabling technologies #Gene editing #Genomics #High Content Screening #High throughput screening #Imaging #Immunology #Immunology / Virology & Vaccines #Lead discovery #Microbiology #Microfluidics #Molecular medicine #Nanomedicine / nanotechnology #Protein chemistry / Proteomics #Screening #Stem cells #System biology #Therapeutics #Translational #Translational chemistry

Engineers use ‘DNA origami’ to identify vaccine design rules

30 June 2020 Image: Glen Carrie In lab tests, virus-like DNA structures coated with viral proteins provoke a strong immune response in human B cells, by Ann Trafton, MIT News Office By folding DNA into a virus-like structure, MIT researchers have designed HIV-like particles that provoke a strong immune… Read More

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#Academic #AI / data analytics / healthtech / informatics #Assay development optimisation & technology #Business #Cellular assays #Drug development #Drug discovery #Enabling technologies #Gene editing #Genomics #High Content Screening #High throughput screening #Imaging #Lead discovery #Microfluidics #RNA #Screening #Stem cells #Therapeutics #Translational #Translational chemistry

Collaboration launches Autobahn Labs, novel early stage drug discovery incubator

29 June 2020 Image: Clay Banks Evotec, Samsara BioCapital, KCK have launched Autobahn Labs, a novel virtual incubator partnering with top academic and research institutions to catalyse early-stage drug discovery and development. Autobahn Labs also announced a first-in-kind strategic collaboration with UCLA Technology Development Group to identify and… Read More

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#Biologics / Biotechnology #Biomarkers #Business #Clinical trials #Drug development #Drug discovery #Lead discovery #Oncology #RNA #Therapeutics #Translational #Translational chemistry

Major boost for AMR Centre as it receives share of Strength in Places Fund award

29 June 2020 Image: Mark Fletcher-Brown The AMR Centre has combined forces to attract investment to combat the global threat of antimicrobial resistance (AMR) resulting in a successful bid for a £114 million project supported by UK Research and Innovation (UKRI) The funding was secured by a North… Read More

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#Academic #Biomarkers #Business #Clinical trials #Drug development #Drug discovery #Lead discovery #RNA #Target validation #Therapeutics

Liverpool scoops £18.6 million research grant to tackle infectious diseases

26 June 2020 Image: Conor Samuel A Liverpool School of Tropical Medicine-led consortium has received an £18.6 million grant from the UK Research and Innovation (UKRI) Strength in Places Fund (SIPF) to deliver a major project to tackle infectious diseases, including COVID-19. The funding award recognises Liverpool City… Read More

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#Clinical trials #Drug discovery #High Content Screening #High throughput screening #Imaging #Lead discovery #Stem cells #System biology

Imaging system produces human cellular morphological data for COVID-19 research

With the COVID-19 pandemic impacting millions around the globe, researchers are racing to develop a vaccine or drug treatment. In an effort to better understand the cellular responses to COVID-19, the digital biology company Recursion has publicly released the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved… Read More

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#Academic #AI / data analytics / healthtech / informatics #Automation / robotics #Business #Cellular assays #Drug development #Drug discovery #Enabling technologies #Gene editing #Genomics #High Content Screening #High throughput screening #Imaging #Lead discovery #Microfluidics #RNA #Screening #Stem cells #Target validation #Therapeutics #Translational #Translational chemistry

Dotmatics acquires BioBright to accelerate laboratory data automation

25 June 2020 Dotmatics has agreed to acquire BioBright, an expert in automating the flow of data from laboratory instruments to a secure cloud. BioBright’s solutions enable scientists to automate the collection of data from in-house and externally networked sources, and then standardise and analyse crucial experimental data… Read More

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#Analysis #Business #Drug development #Drug discovery #Lead discovery

Applied Photophysics and Fluorescence Innovations make protein stability systems

24 June 2020 Image: Sincerely Media Applied Photophysics (APP) and Fluorescence Innovations (FI) have entered into a joint venture agreement to develop and produce protein stability systems for leading researchers and industries around the globe. The two firms said they will be equal partners in the new initiative. Read More

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