Resources

Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterisation of small molecule modulators have aided these efforts.   The Transcreener ADP² Kinase Assay meets this need as it relies on direct ADP detection to measure the activity […]

SAMDI Tech’s radioactivity assays overcome key challenges in drug discovery by offering key solutions, including: Detecting low amounts of product with sensitive assays Generating data rapidly with high-throughput, 384-well capabilities Characterising potent inhibitors by benefiting from lower enzyme concentrations In this free to download TechNote, learn how SAMDI Tech’s radioactivity assay characterised low turnover methyltransferase […]

In immunoassays-based research, immunodiagnostics, as well as immunotherapy, one of the highly critical aspect of antibodies is their reproducible performance. Antibody reproducibility is driven by their specificity and several other factors ranging from antibody design to target validation. This NEW eBook Antibody Production gives you an overview of the antibody’s life cycle by covering the following sub-topics: […]

Discover how process optimisation utilising automated synthetic biology solutions can remove the antibody sequence cloning bottleneck that divides high-content lead identification and downstream high throughput characterisation. If your work involves antibody discovery or process improvement in recombinant cloning don’t miss this whitepaper illustrating how Codex DNA’s synthetic biology solutions can accelerate antibody discovery workflows. In […]

Discover how Central and Eastern Europe (CEE) provides an attractive environment to conduct clinical studies of any phase while partnered with a local CRO. Research Professionals’ Managing Partner, György Barta (PharmD) discusses the many benefits of conducting clinical studies in CEE as well how Research Professionals, a leading CRO with operations in Hungary, Poland, Romania, […]

Drug discovery contract research organizations (CROs) offer an established infrastructure and experience that offers promising paths forward for various research projects. However, partnering with a CRO also presents key challenges, and companies should consider three questions: How long until data is delivered? Will the quality of the data instill confidence in a critical go/no-go decision? […]

Finding an encouraging drug lead that selectively engages a target of interest is the result of several critical matches that lead to successful drug discovery programmes, including: Matching a small molecule library with an innovative assay technology Matching a primary screening platform with orthogonal assays to validate hits Matching a drug discovery company with a […]

Vaccination is the most effective method of preventing infectious diseases, and is considered one of the greatest achievements in medicine. Until today, various vaccines against several crucial diseases (including influenza, chicken pox, or HPV) have been developed that save millions of lives.   The continuous emergence of new diseases and concerns regarding safety, vaccine research and development became […]

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury (DILI) remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, we and others have demonstrated the […]

From basic to translational research and clinical applications, cell culture is an essential technique that underpins the generation of promising cell and gene therapies. Since the quality of cytokines and growth factors can significantly influence the properties and function of cultured cells, these bioactive proteins must be produced to the highest standards to ensure the same reproducible […]

European Pharmacopoeia (Ph. Eur.) General Chapter 2.1.7 Balances for Analytical Purposes was published in July 2021. Compliance with this chapter by January 1, 2022 is mandatory for any pharmaceutical company who manufactures in, or exports into, the European market.   Balances for Analytical Purposes aims to ensure quality control of medicines in European member states. The requirements of Ph. Eur. are similar […]

Vaccination is the most effective method of preventing infectious diseases, and is considered one of the greatest achievements in medicine. Until today, various vaccines against several crucial diseases (including influenza, chicken pox, or HPV) have been developed that save millions of lives. Along the continuous emergence of new diseases and concerns regarding safety, vaccine research […]

John Conway of 20/15 Visioneers tackles defining “What Makes a Great BioELN” in this thoughtful and informative industry perspective. Learn: The six high-level workflows a great BioELN must include What are the team personas who must get utility from a new BioELN The 3 key qualities necessary to have in place before seeking a BioELN […]

Leading research from European Journal of Lipid Science and Technology How many different types of diseases are there in the world? How will we ever be able to find cures for them? We might not be able to do so for all of them, but we may be able to develop better treatments. Scientific and […]

High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. In this whitepaper, SAMDI Tech CSO, Zack Gurard-Levin, discusses the important aspects to consider when choosing the right methodology for drug discovery. Learn: Traditional label-dependent approaches vs. novel label-free technologies How researchers determine which methodology offers the most promising path […]