Combining human iPSC-derived neurons with multi-electrode array (MEA) assays can provide powerful insights into synaptic connectivity, network dynamics, and functional maturation. However, MEA experiments can be challenging, with small changes in cell culture conditions dramatically impacting results. In this expert guide, bit.bio’s Field Applications Scientist shares key considerations for improving… Read More
Explore obesity case studies profiling semaglutide, tirzepatide, and retatrutide using Eurofins Discovery’s weight-loss solutions. Advance your obesity program with on/off-target panels, translational assays, in vivo models, and MOA-reflective tools. Partner with expert scientists and program managers for strategic guidance and scientific leadership on your integrated drug discovery programs targeting weight-loss… Read More
Discover how the Agilent BioTek Cytation cell imaging multimode reader and ViQi’s AVIA provide a powerful, integrated solution for viral infectivity analysis. Download the application note to explore how this innovative approach offers key advantages over traditional assays, including: High-throughput, cost-effective analysis: AVIA minimizes reagent use, incubation time, and replicate needs,… Read More
Delve into our case studies on ADC Synthesis, Development, and Characterization, where we reveal how: Trastuzumab-based ADCs with multiple payload linkers demonstrated specific, targeted functional activity. Flow cytometry and internalization assays confirmed antigen targeting and cellular uptake. Cytotoxicity assays revealed nanomolar IC50s only in HER2+ cell lines, confirming ADC efficacy… Read More
VOLTA Scanner is transforming cardiac safety testing. This whitepaper describes an optophysiology instrument, supporting stable, fast, high-resolution toxicity testing and drug development. Download to learn how: VOLTA detects early-after-depolarizations (EADs), and predicts QT/QRS risk Optogenetic pacing improves assay precision Automated, HPT optophysiological screening streamlines decisions… Read More
See how Cerno MassWorks™ delivers sub-millidalton mass accuracy and >99% spectral accuracy—enabling formula ID on standard LC/MS systems. This detailed application note walks you through the results, method, and impact. Confidently identify unknowns using spectral accuracy Extend the power of your existing single quad LC/MS Eliminate reliance… Read More
Discover a new generation of molecular sensing technology from Oxford Nanopore Technologies that is transforming the biopharma development pipeline. You’ll explore: How Oxford Nanopore sequencing overcomes challenges faced in the drug development process Advantages of a single-platform solution End-to-end workflows that can be applied to each… Read More
Facing challenges with macrophage differentiation from iPSCs? Discover valuable insights in our mini review ‘Optimising Macrophage Differentiation from iPSCs with X-VIVO® Media.’ Get the guidance you need to overcome these obstacles to address challenges regularly faced by scientists, from drug discovery to QA/QC. Brought to you by … Read More
In this technical note you will learn more about: Targeted and efficient endotoxin removal: EtoxiClear® is a highly effective chromatography affinity adsorbent, specifically designed to remove low residual levels of endotoxins across a variety of biopharmaceutical processes, ensuring high product purity Scalability and cost-effectiveness: Designed for both small and large-scale… Read More
Struggling to make sense of the strategies, technology and trade-offs when developing a DNA supply chain? Elegen created a comprehensive overview of the evolving field of gene synthesis. This guide contains a detailed comparison of 10 industry-leading vendors, including key metrics such as error rate, turnaround time, cost, and maximum… Read More
Unlock the Power of Humanised Immune System Mice Traditional mouse models have limitations in recapitulating human biology — but humanised immune system (HIS) mice offer a more predictive approach. These advanced models bring you closer to clinical relevance. Download this whitepaper to discover: The evolution of immunodeficient mice Key humanisation… Read More
Scale Bio’s ScalePlex technology and Single Cell RNA Sequencing Kit v1.1 are revolutionising drug discovery by making large-scale single cell sample and condition screening possible. Libraries from 384 drug conditions were prepared in just 1.5 days 90% reduction in processing time >80% cell recovery rate and >3000 unique transcripts per… Read More
This whitepaper offers expert guidelines for analysing GPCR second messenger data: Detailed comparison of four data analysis methods Practical case studies for method application Specific insights for high-throughput screening and medicinal chemistry Brought to you by… Read More
The Newcells Renal Proximal Tubule Cells Model eBook covers topics including: Cross-species comparison of drug handling Transporter mediated drug-drug interactions Drug-induced renal toxicity New drug modalities e.g. RNA therapeutics and how to measure mitochondrial health Brought to you by Copyright… Read More
In “Three Ways to Solve Scientific FOMO: Advice for Navigating Early Discovery,” we explore key functions that empower researchers to overcome the challenges of siloed data, including: Leveraging ontologies Utilising search alerts Effectively employing AI Read our ebook to learn how you can accelerate your breakthroughs in drug discovery. … Read More
As antibody therapeutics evolve, new formats such as bispecific antibodies (bsAbs) and Fab fragments offer new and exciting therapeutic opportunities. However, traditional mAb isolation methods are often ineffective, necessitating innovative solutions. This article explores these challenges and introduces Astrea Bioseparations’ Fabsorbent™ F1P HF as an alternative strategy for isolating next-generation… Read More
