White paper: Improve the drug discovery tool box

Making good decisions in the drug discovery process requires software to effectively manage the size and complexity of multiparametric datasets. Companies that most quickly and accurately identify key drug discovery parameters will win the race to identify the most appropriate targets and develop medicines to affect them.

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Automation that connects your drug discovery workflow

Scientific and technological advancements continue to emphasise the importance of automation, both in the physical and digital world. Given recent discussions about the lab of the future, the benefits have expanded to highlight how automation can support greater connectivity between data and workflows, paving the way to a ‘smarter lab’. A fully integrated robotic platform […]

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App Note

Maximize your productivity with high-throughput flow cytometry automation

High-throughput flow cytometry technologies have revolutionized drug screening, says Bio-Rad. This application note explains how you can take throughput and reproducibility to the next level using the ZE5 Cell Analyzer. In the current environment, with increased pressures on drug companies, Bio-Rad believes using effective automation is critical. Featured in this application note: How integration of […]

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Linking genomics with proteomics to accelerate the search for drug targets

A summary of three recently published research studies that highlight the importance of linking genetic and protein expression data in the context of disease phenotypes in order to identify new, robust drug targets. While many drugs are developed based on genomic findings, it’s common for these drugs to fail in the clinical phase due to […]

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Horizon’s iPSC cell line engineering services

Horizon can help researchers work with the biologically relevant cell models (immune cells, induced pluripotent derived cardiac and neural cells, and organoids) that closely mimic the end-stage biology of interest. With over a decade of CRISPR/Cas cell line engineering experience, Horizon’s iPSC editing platform is designed to enable efficient and precise genomic modifications in a […]

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A rapid method to quantitatively screen bispecific antibody using protein A and His1K biosensors

Recent biotechnological advances have fueled development bispecific antibodies (bsAbs) in the last 10 years. However, the functional analysis of bsAbs during bioprocessing adds a challenge for scientists given the wide array of bsAbs populated by many different species, comprising many different formats, and that traditional SPR and ELISA methods for bsAbs evaluation are time consuming. […]

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Understanding T cell phenotype and function to enable improved therapeutics

The human body has the capacity to produce an array of specialized T cells, which provide unique responses to a diverse range of tumour cells and pathogens. The modulation of T cells is an exciting prospect for the development of novel therapies for immuno-oncology –autoimmune applications, adoptive cell therapy and vaccine development. Download here

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Accurate affinity profiling of a SARS-CoV-2 antibody in serum

The ability to accurately characterise the immune response against SARS-CoV-2 is of vital importance in managing the current COVID-19 pandemic. Measuring antibody affinity under physiologically relevant conditions in complex mixtures like serum remains challenging but is critically important to furthering our understanding of the immune response and protection window in patients and vaccinated individuals. In […]

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Syngeneic mouse models for preclinical immuno-oncology

The advent of immuno-oncology has necessitated changes in the types of animal models used in oncology drug discovery. Syngeneic models—inbred mice bearing an engrafted tumour derived from a genetically identical mouse strain—are invaluable preclinical research tools that enable tumor studies in the context of a complete and functional immune system. These models are powerful tools […]

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OMNImet·GUT: enables at-home collection and ambient temperature transport of fecal samples for metabolomics

In this whitepaper, Metabolon describes the evaluation of OMNImet·GUT as an at-home collection device for ambient temperature transport of samples for fecal metabolomics analysis. Compatibility with Metabolon’s global metabolomics platform and quantitative SCFA assay is also demonstrated.

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Live-Cell Analysis Training Video: From Culture to Assay

Cell-based assay research in pharma and academia, depends on forms of measurement of living cells. As soon as cells are placed in culture, there is opportunity to learn about or monitor the cells prior to analysis. Live-Cell Analysis enables real-time analysis with full cell tracking workflows.

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Guide: 5 Ways Biophysical tools help brain studies

Guide: 5 Ways Biophysical tools help brain studies Sponsored by Nanotemper, 8 June 2020 Learn how scientists gain insight into the molecular mechanisms of protein misfolding and aggregation- a hallmark of neurodegenerative diseases by using biophysical tools to analyze molecular interactions and thermal stability. This eBook looks at research from five peer-reviewed publications. If you […]

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New antibody internalization advanced screening method provides greater speed & insight

New antibody internalization advanced screening method provides greater speed & insight 26 May 2020 Sponsored by Sartorius Researchers abilities to improve the breadth of therapeutic antibodies have been aided by innovative technologies for antibody discovery, for instance, through humanization of mouse antibodies and phage display. However, advanced antibody design techniques create the need for new […]

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