Resources

""
Infographic

Stability assessment of biologics during early development workflows

During early development of biologics, there are a large number of attributes researchers evaluate, but some of the most common centre around stability – asking if a biologic is well-folded, active and pure in its buffer, and whether it remains that way over time. Biophysical characterisations are valuable for providing this information without using a […]

Download the infographic
""
App Note

Measurement of mitochondrial toxicity using primary hepatocytes

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. In this App […]

Download the App Note
""
App Note

Learn about the rapid bioenergetic functional screening of anticancer drug candidates

The regulation of cellular bioenergetics is recognised as a key driver of cancer cell proliferation. Identifying key pathways that modulate bioenergetic metabolism is a promising strategy for developing novel therapeutics for cancer treatment. In this App Note you will learn: How the Agilent Seahorse XF Real Time ATP rate assay provides a simple robust workflow […]

Download the App Note
""
App Note

Optimising kinetic assays to avoid avidity effects

What you will learn: Researchers from ChromoTek discuss the differences between affinity and avidity as measured on the Octet® BLI platform Measuring affinity in avidity driven assay orientations Why assay orientation, valency, ligand surface density and non-specific binding matter Recognise and resolve issues arising from interactions that contain a bivalent or multivalent component

Download the App Note
""
App Note

Discover how to achieve mRNA binding on Oligo dT with DBC values over 6mg/mL

In this Application Note, multi-parallel screening of binding conditions on CIM® Oligo dT 96-well plates was performed to optimise the dynamic binding capacity (DBC) in the shortest time possible. What you will learn: How to effectively use Monolithic 96-well plates when developing methods. They are unique on the market in combining the standard well-plate design with monolithic […]

Download the App Note
""
App Note

Streamline migration assays with in-incubator monitoring

Cell migration assays can be time-consuming and challenging, from identifying and ensuring assays are imaged at the appropriate time, to properly measuring wound closure. Evident’s CM cell culture monitors provide label-free, quantitative results, consistent results throughout your lab, and are cost-effective. Researchers at ACEL simplified the cell migration process by using Evident’s CM cell culture […]

Download the App Note
""
eBook

Analytical methods for viral vector development and manufacturing in gene therapy

In the eleventh eBook of the Hamilton series ‘Analytical Methods for Viral Vector Development and Manufacturing in Gene Therapy’, we learn about: Gene therapy: history, viral vectors and the role of CDMOs Automation of analytical assays during viral vector development and manufacturing The solutions that Hamilton offers to customers working in this field, both in […]

Download the eBook
""
eBook

Binding kinetics in hours instead of days with label-free interaction analysis

Label-free interaction analysis takes discovery to a new level. It removes inaccuracies and inefficiencies, but it also uncovers a new layer of insight into the kinetic activity and binding specificity of a greater range of analytes. GCI technology brings you closer to your analytes, allowing you to see interactions in their truest form.

Download the eBook
""
Whitepaper

Discover evidence-based, first-in-human dose selection

This whitepaper discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models and emphasises the importance of accurate dose prediction to ensure patient safety and trial success. In this whitepaper you will learn about: The significance of selecting appropriate starting doses in clinical trials. Utilising humanised mouse models […]

Download the Whitepaper
""
Whitepaper

Explore the power of digital PCR for lentiviral vector characterisation

Recombinant lentiviral vectors are used for ex vivo transgene delivery in several gene-modified cell therapies, such as chimeric antigen receptor (CAR) T cell therapy. Reliable analytical methods such as digital PCR to characterise lentiviral vectors and the cells transduced with them are critical to helping ensure the safety and efficacy of these biologics. Download this new […]

Download the Whitepaper
""
Guide

The biologics researcher’s mini-guide to screening candidates with nanoDSF

Among the most common critical quality attributes (CQAs) for early developability assessment is thermal stability. One particular tool for assessing thermal stability with high resolution is nano-differential scanning fluorimetry (nanoDSF). Read this mini-guide to learn: How nanoDSF uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton Why high-resolution […]

Download the Guide
""
Poster

Accelerated production of functional microglia from reprogrammed hiPSCs

In this scientific Poster, just revealed at ISSCR 2023, you will discover: How precision reprogramming generates consistent, functional human microglia (ioMicroglia) from iPSCs in just 10 days Independent validation that ioMicroglia undergo phagocytosis of both E. coli particles and amyloid beta particles Independent validation that ioMicroglia show a pro-inflammatory cytokine response to various disease-relevant stimuli […]

Download the Poster
""
Guide

Unlock the full potential of your preclinical oncology studies with a humanized mouse model

With an attrition rate of up to 95% for oncology drug development, it is evident that significant barriers still exist when it comes to translating preclinical investigation findings to in-human trials. Our Guide explores how humanized mouse models can help accelerate the successful development of novel, safe, and effective treatments for oncology by generating human-relevant […]

Download the Guide
""
Whitepaper

5 reasons your organisation needs a modern medical imaging infrastructure

How can you reduce timelines for R&D? Tackle your enterprise’s siloed and disorganised imaging data. Maximise the value of data in your archives and stop spending weeks on mundane data-wrangling tasks. We’ve compiled a list of the top 5 stumbling blocks for working with medical imaging. This whitepaper digs into the ways that a modern […]

Download the Whitepaper
""
Case Study

PanHunter: Your enterprise solution to find the detail that matters

The study of health and disease through multi-omics research generates vast amounts of interconnected data. Unlocking their secrets requires complex bioinformatic exploration. This analysis is accelerated by a dedicated and flexible software application that is not only reliable and provides reproducible results, but also facilitates collaboration between project investigators and their teams. To this end, […]

Download the Case Study
""
Case Study

Unlocking the potential of bispecific T-cell engagers: Efficacy and safety insights revealed

Discover the groundbreaking findings from a study on bispecific T-cell engagers conducted by The Jackson Laboratory. This case study delves into the tools available for assessing cytokine release and tumour growth inhibition. Explore the implications of donor-specific responses and how this knowledge can optimise the development of immunomodulatory therapeutics. What you will learn: The correlation […]

Download the Case Study