Resources

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Whitepaper

Discover evidence-based, first-in-human dose selection

This whitepaper discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models and emphasises the importance of accurate dose prediction to ensure patient safety and trial success. In this whitepaper you will learn about: The significance of selecting appropriate starting doses in clinical trials. Utilising humanised mouse models […]

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Whitepaper

Explore the power of digital PCR for lentiviral vector characterisation

Recombinant lentiviral vectors are used for ex vivo transgene delivery in several gene-modified cell therapies, such as chimeric antigen receptor (CAR) T cell therapy. Reliable analytical methods such as digital PCR to characterise lentiviral vectors and the cells transduced with them are critical to helping ensure the safety and efficacy of these biologics. Download this new […]

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Guide

The biologics researcher’s mini-guide to screening candidates with nanoDSF

Among the most common critical quality attributes (CQAs) for early developability assessment is thermal stability. One particular tool for assessing thermal stability with high resolution is nano-differential scanning fluorimetry (nanoDSF). Read this mini-guide to learn: How nanoDSF uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton Why high-resolution […]

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Poster

Accelerated production of functional microglia from reprogrammed hiPSCs

In this scientific Poster, just revealed at ISSCR 2023, you will discover: How precision reprogramming generates consistent, functional human microglia (ioMicroglia) from iPSCs in just 10 days Independent validation that ioMicroglia undergo phagocytosis of both E. coli particles and amyloid beta particles Independent validation that ioMicroglia show a pro-inflammatory cytokine response to various disease-relevant stimuli […]

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Guide

Unlock the full potential of your preclinical oncology studies with a humanized mouse model

With an attrition rate of up to 95% for oncology drug development, it is evident that significant barriers still exist when it comes to translating preclinical investigation findings to in-human trials. Our Guide explores how humanized mouse models can help accelerate the successful development of novel, safe, and effective treatments for oncology by generating human-relevant […]

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Whitepaper

5 reasons your organisation needs a modern medical imaging infrastructure

How can you reduce timelines for R&D? Tackle your enterprise’s siloed and disorganised imaging data. Maximise the value of data in your archives and stop spending weeks on mundane data-wrangling tasks. We’ve compiled a list of the top 5 stumbling blocks for working with medical imaging. This whitepaper digs into the ways that a modern […]

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Case Study

PanHunter: Your enterprise solution to find the detail that matters

The study of health and disease through multi-omics research generates vast amounts of interconnected data. Unlocking their secrets requires complex bioinformatic exploration. This analysis is accelerated by a dedicated and flexible software application that is not only reliable and provides reproducible results, but also facilitates collaboration between project investigators and their teams. To this end, […]

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Case Study

Unlocking the potential of bispecific T-cell engagers: Efficacy and safety insights revealed

Discover the groundbreaking findings from a study on bispecific T-cell engagers conducted by The Jackson Laboratory. This case study delves into the tools available for assessing cytokine release and tumour growth inhibition. Explore the implications of donor-specific responses and how this knowledge can optimise the development of immunomodulatory therapeutics. What you will learn: The correlation […]

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Guide

How to build an effective protein degrader

The development of a successful PROTAC candidate requires overcoming challenges at each stage of development. Read this guide to learn about common roadblocks, technologies to overcome them, and how to ensure you’re on the right track to building an efficient protein degrader. Download this guide to learn about: The most common roadblocks at key stages […]

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eBook

An introduction to organ-on-a-chip technology

Download Emulate’s Introduction to Organ-on-a-Chip Technology eBook to learn about: What Organ-Chips are, how they work, and why they are transforming the way drugs are discovered and developed How Organ-Chips overcome the main challenges of conventional in vivo and in vitro models The wide variety of insights and endpoint analyses Organ-on-a-Chip technology provides Real-world examples […]

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eBook

How to become a PCR pro

The term ‘PCR’ has been on everybody’s lips since the outbreak of the Covid-19 pandemic, but only laboratory professionals know how difficult it can be to achieve success with this well-established technique. If your PCR reactions are driving you to despair, look no further than INTEGRA’s comprehensive eBook! Learn more about: How PCR works Factors […]

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Infographic

Learn new ways to identify mitochondrial liability

Download our mitochondrial toxicity infographic and discover the benefits of novel in vitro strategies for consumer safety. Drug-induced mitochondrial dysfunction has been linked to compound attrition, organ toxicity, black-box warnings, and market withdrawals. Our infographic will help you: Gain an historical perspective on mitochondrial toxicity. Understand the importance of testing in early-phase drug discovery. Learn […]

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App Note

Kinetically quantify neuronal outgrowth using live-cell analysis

Monitoring neuronal morphology in long-term in vitro cell cultures is critical for characterisation and evaluation of disease models and to understand neuronal development. Ideally, approaches to track neurite dynamics would allow continuous automated measurements of structural parameters, including neurite length and number of branch points. These methods should be non-perturbing and enable quantification of neurons […]

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Guide

Four cell culture hacks to get the best out of your neurons

Make your iPSC-derived glutamatergic neuron cultures a success every time with these tips from a neuronal cell culture expert. In this Guide, you will learn: How to prevent glutamatergic neurons from detaching from culture surfaces How to formulate extracellular matrix coatings to promote cell adherence The best timings for media changes, especially when the unexpected […]

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eBook

Imaging protocol handbook

This guide will provide you with: A quick and easy way to find the most used and trusted protocols for imaging A go‑to resource for reliable methods Step‑by‑step methods to enable your imaging success

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eBook

Electronic lab notebook buyer’s guide & checklist

You’re in R&D, so you know the key to success is mastering your workflow. With so many different tasks to keep track of, it’s easy to feel overwhelmed and bogged down by manual data entry, paper-based processes, and transcription errors. You’ve heard of ELNs, but you may be unfamiliar with how they can help streamline […]

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