Resources

Download our mitochondrial toxicity infographic and discover the benefits of novel in vitro strategies for consumer safety. Drug-induced mitochondrial dysfunction has been linked to compound attrition, organ toxicity, black-box warnings, and market withdrawals. Our infographic will help you: Gain an historical perspective on mitochondrial toxicity. Understand the importance of testing in early-phase drug discovery. Learn […]

Monitoring neuronal morphology in long-term in vitro cell cultures is critical for characterisation and evaluation of disease models and to understand neuronal development. Ideally, approaches to track neurite dynamics would allow continuous automated measurements of structural parameters, including neurite length and number of branch points. These methods should be non-perturbing and enable quantification of neurons […]

Make your iPSC-derived glutamatergic neuron cultures a success every time with these tips from a neuronal cell culture expert. In this Guide, you will learn: How to prevent glutamatergic neurons from detaching from culture surfaces How to formulate extracellular matrix coatings to promote cell adherence The best timings for media changes, especially when the unexpected […]

This guide will provide you with: A quick and easy way to find the most used and trusted protocols for imaging A go‑to resource for reliable methods Step‑by‑step methods to enable your imaging success

You’re in R&D, so you know the key to success is mastering your workflow. With so many different tasks to keep track of, it’s easy to feel overwhelmed and bogged down by manual data entry, paper-based processes, and transcription errors. You’ve heard of ELNs, but you may be unfamiliar with how they can help streamline […]

Cell therapy research has never been more exciting with all of the research ongoing. Learn more about the trends, insights, and perspectives from ACROBiosystems as a manufacturer of cell therapy reagents, including topics like: CAR-NK research Developing new CAR constructs Evaluation CAR expression detection Role of GMP Manufacturing in cell therapy

Download this eBook to learn more about process development and manufacturing in the mRNA space to enable successful scale-ups of mRNA production for therapeutic applications. Topics covered in the eBook include: Expert views on mRNA development and manufacturing Advantages of mRNA processes compared to traditional vaccine manufacturing Best practices for scale up of in vitro […]

Given the potential of emerging advanced therapies, market demand is likely to continue to grow. Generating the required quantity of cells efficiently becomes even more challenging when the cells of interest are attachment-dependent, such as induced pluripotent stem cells (iPSCs). The choice of cell culture platform will have significant operational and commercial impacts. Download this […]

This is an extraordinarily exciting time to be involved in precision medicine for cancer. This new whitepaper reviews some of the topics and trends in this emerging research area, including: 3D cultures: Spheroids and organoids Organoids in cancer research Tumour microenvironments Organ-on-a-chip and body-on-a-chip 3D bioprinting

Currently, no effective cure or treatment for Huntington’s disease exists. To accelerate Huntington’s disease research and drug discovery, researchers need access to physiologically relevant human disease models that recapitulate patient phenotypes, in combination with more advanced methods to understand the underlying mechanisms of the disease. In this App Note you will learn: How Charles River […]

Download the guide for hit-finding tools that will accelerate your hit to lead and lead optimisation programs for CNS, metabolic, oncology and other therapeutic areas. Synthetic, medicinal, and computational chemistry capabilities along with in house available diversity and focused libraries Small molecule and biologics targeted screening for GPCRs, kinases, ion channels, interleukins, checkpoints, novel targets […]

In this whitepaper, we present the unique benefits of the high-throughput iQue®Advanced Flow Cytometry Platform, combined with built-in, visual-based iQue Forecyt®software, in the antibody discovery workflow. Learn analysis details of: Antibody Binding Antibody Internalisation and Viability ADCP Measurement in Adherent Cells ADCP Measurement in Suspension Cells Quantification of NK Cell-Mediated ADCC Antibody-Mediated T Cell Activation

Download the latest Mirus Bio whitepaper to learn about: The differences between gene delivery methods (electroporation, chemical transfection and viral transduction). Optimising electroporation with the Ingenio(R) EZporator(R) Electroporation System. Electroporate multiple cell types with high efficiency and viability. Deliver different molecular cargo.

Download the App Note to learn about: How to create and share an automated workflow for rapid development and validation of SARS-CoV-2 clinical diagnostics. The highly scalable liquid handling platform, CyBio FeliX for clinical diagnostics – it provides magnetic bead-based nucleic acid extraction, eliminating laborious and time-consuming column-based binding and spinning steps. Automating your diagnostic […]

In the Quality by Design (QbD) approach to antibody-based therapeutics development, stability characterisation —the probability of a protein unfolding or denaturing— is performed to ensure that structure and function are preserved throughout development and manufacturing.  Antibodies are affected by many factors along their journey to become therapeutics. Stability characterisation assays are therefore pivotal to determine […]