Resources

Case Study

Partnering with drug discovery service providers: challenges and solutions

Drug discovery contract research organizations (CROs) offer an established infrastructure and experience that offers promising paths forward for various research projects. However, partnering with a CRO also presents key challenges, and companies should consider three questions: How long until data is delivered? Will the quality of the data instill confidence in a critical go/no-go decision? […]

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Case Study

Pairing the Right Small Molecule Library with Innovative High-Throughput Screening Creates More Therapeutic Opportunity

Finding an encouraging drug lead that selectively engages a target of interest is the result of several critical matches that lead to successful drug discovery programmes, including: Matching a small molecule library with an innovative assay technology Matching a primary screening platform with orthogonal assays to validate hits Matching a drug discovery company with a […]

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Brochure

Cubis Laboratory Balances in Vaccine Research and Development

Vaccination is the most effective method of preventing infectious diseases, and is considered one of the greatest achievements in medicine. Until today, various vaccines against several crucial diseases (including influenza, chicken pox, or HPV) have been developed that save millions of lives.   The continuous emergence of new diseases and concerns regarding safety, vaccine research and development became […]

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App Note

Ready-to-go spheroids + media for drug discovery

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury (DILI) remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, we and others have demonstrated the […]

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Whitepaper

Batch-to-batch consistency: premium grade bioactive proteins

From basic to translational research and clinical applications, cell culture is an essential technique that underpins the generation of promising cell and gene therapies. Since the quality of cytokines and growth factors can significantly influence the properties and function of cultured cells, these bioactive proteins must be produced to the highest standards to ensure the same reproducible […]

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Whitepaper

Weighing in Compliance with European Pharmacopoeia Chapter 2.1.7

European Pharmacopoeia (Ph. Eur.) General Chapter 2.1.7 Balances for Analytical Purposes was published in July 2021. Compliance with this chapter by January 1, 2022 is mandatory for any pharmaceutical company who manufactures in, or exports into, the European market.   Balances for Analytical Purposes aims to ensure quality control of medicines in European member states. The requirements of Ph. Eur. are similar […]

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Brochure

Cubis Laboratory Balances in Vaccine Research and Development

Vaccination is the most effective method of preventing infectious diseases, and is considered one of the greatest achievements in medicine. Until today, various vaccines against several crucial diseases (including influenza, chicken pox, or HPV) have been developed that save millions of lives. Along the continuous emergence of new diseases and concerns regarding safety, vaccine research […]

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Whitepaper

An industry perspective by 20/15 Visioneers, a leading science and technology consulting firm

John Conway of 20/15 Visioneers tackles defining “What Makes a Great BioELN” in this thoughtful and informative industry perspective. Learn: The six high-level workflows a great BioELN must include What are the team personas who must get utility from a new BioELN The 3 key qualities necessary to have in place before seeking a BioELN […]

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Whitepaper

Leaving the Wild West Era of Lipidomics

Leading research from European Journal of Lipid Science and Technology How many different types of diseases are there in the world? How will we ever be able to find cures for them? We might not be able to do so for all of them, but we may be able to develop better treatments. Scientific and […]

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Whitepaper

Disrupting Drug Discovery From Assay Development to Lead Compound

High-throughput screening remains one of the most powerful, unbiased approaches for small molecule drug discovery. In this whitepaper, SAMDI Tech CSO, Zack Gurard-Levin, discusses the important aspects to consider when choosing the right methodology for drug discovery. Learn: Traditional label-dependent approaches vs. novel label-free technologies How researchers determine which methodology offers the most promising path […]

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Infographic

Do you need a custom monoclonal antibody for your next project?

Selecting the right custom antibody provider is an important decision. It can mean the difference between a breakthrough or failure. That’s why it matters in how and where your antibodies are made. Learn what sets Bethyl custom monoclonal antibodies quality and service apart. Discover the top reasons why you should choose Fortis Life Science for […]

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Whitepaper

Advancing quantitative analysis of targeted protein degrader compounds

Small molecule drug discovery is expanding beyond traditional strategies focused on identifying compounds that inhibit or block the activity of proteins that cause disease. A newer approach is to selectively target proteins for removal from the cell using degrader compounds. Proteolysis Targeting Chimeras (PROTACs) and immunomodulatory (IMiD) molecular glues are examples of small molecule degraders […]

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Article

Finding a needle in the haystack: identifying actionable biomarkers from the plasma proteome

In a study published in Neurology, a group from Alnylam Pharmaceuticals used large-scale protein screening assays to simultaneously analyse many proteins in vast numbers of patient serum samples. This cutting-edge approach allowed them to discover a novel biomarker of hereditary transthyretin-mediated (ATTRv) amyloidosis disease onset and progression. ATTRv amyloidosis, caused by mutation of the transthyretin […]

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Whitepaper

Whitepaper: FDA guidelines for GMP of API

One of the key elements of quality control in pharmaceutical manufacturing is cGMP compliance. As your product moves closer to market, cGMP requirements change and become more stringent. Dalton Pharma Services has created a whitepaper to download, FDA Guidelines for GMP of API. Featured in this whitepaper: API and GMP overview FDA API regulations including: […]

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App note

Cell culture just got smarter

The OLYMPUS Provi CM20 incubation monitoring system can be used to develop methods for efficient quality control and data management within your cell culture workflow. In this application note, discover how the quantitative data collected from the CM20 enabled users to compare and detect variable efficiency of differentiation of Human iPS cell lines for generation […]

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Article

Systems-level analyses reveal that children with the COVID-associated inflammatory syndrome, MIS-C, display a unique immunological profile

Olink has created a summary article of a study recently published by Consiglio et al. in Cell. This study focuses on the rare cases when children develop Multisystem Inflammatory Syndrome in Children (MIS-C) in response to infection by the SARS-CoV-2 virus. Typically in these cases the syndrome manifests four to six weeks after infection, producing […]

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