Resources

In the Quality by Design (QbD) approach to antibody-based therapeutics development, stability characterisation —the probability of a protein unfolding or denaturing— is performed to ensure that structure and function are preserved throughout development and manufacturing.  Antibodies are affected by many factors along their journey to become therapeutics. Stability characterisation assays are therefore pivotal to determine […]

Currently, at least 35 glycoengineered antibodies, with their Fc fucose partially or entirely removed, have been investigated in animal models or clinical trials. The absence of fucose on the Fc N-glycan increases IgG1 Fc binding affinity to the FcγRIIIa on immune effector cells like natural killer cells. It results in increased antibody-dependent cellular cytotoxicity (ADCC). […]

As experimental data becomes bigger and more complex, scientists are challenged to make discoveries faster, consistently document and analyse their work, and easily collaborate across an organisation and with external partners. Electronic lab notebooks (ELN) provide access to all collaborators 24/7, wherever they are and whether they are employees or at contract organisations. If an […]

This whitepaper, brought to you by The Jackson Laboratory will teach: The benefits of the JAX NSGTM-MHC I/II KO mouse platform humanised with pre-characterised PBMCs How this platform can support a wide range of immunological studies, especially those containing T cells responses The versatility of this platform to various research disciplines

Download this App Note from Analytik Jena to learn about: Detection of lipid changes in microglia cells in generating therapeutic approach towards neuroinflammation diseases Application of label-free matrix-assisted laser desorption/ionisation (MALDI) MS cell fingerprinting workflows or cellular assays capable of characterising drug off-target responses with high throughput sample preparation done by Cybio FeliX Workflows to investigate […]

Learn best practices to consider for organoid work, as well as how to use Corning Matrigel matrix and other products to support research. Organoids have gained popularity over the years due to their ability to self-organise into “mini-organs” capable of recapitulating their respective organ-specific functions. Products such as Corning Matrigel matrix can help streamline workflows for […]

Download this App Note from Thermo Fisher Scientific to discover an electroporation system that can: Meet requirements for commercial manufacturing processes Be integrated with a range of products and tools designed for use in cell therapy manufacturing Optimise the cell engineering step of your manufacturing process  

Download the Poster to discover more about: scRNAseq and analysis with enriched, purified cells leads to better data, often uncovering data points that may be obscured by dead cells and debris Engraftment in PDX models with enriched cells achieved > 95% success rate using 10-20x less cells while shortening the engraftment period by 50% Lentiviral transduced […]

The ability to monitor biologic candidates’ propensity towards self-association is critical for predicting whether a therapeutic is likely to aggregate or become difficult to administer due to viscosity. Read how Merck KGaA uses light scattering measurements to predict how formulations will behave at clinically relevant concentrations and find the optimal formulation buffer for their biologics […]

Current methods to generate cells from human-induced pluripotent stem cells (iPSCs) lack reproducibility and scalability. This raises challenges for disease research, drug discovery and cell therapy development due to unreliable data and long experimental timelines. However, there is a new technology on the block, enabling reproducible, consistent and scalable production of physiologically relevant human cell […]

NanoTemper outlines four questions to ask yourself to ensure you’re on the right track Working in PROTACs, you’re tasked with the most challenging targets — that aim to address intractable diseases such as cancer, Alzheimer’s, or Parkinson’s disease. Despite the impressive promise of PROTACs, you still have to overcome many hurdles in order to work […]

This whitepaper brought to you by Mirus Bio details the multiple approaches developers can use to verify the quality and functionality of viral assays. Download the latest Mirus Bio whitepaper to learn about: Methods to characterize lentivirus and adeno-associated virus Differences between physical and functional assays of virus How to perform an infectivity assay to […]

Drug-induced mitochondrial dysfunction has been linked to compound attrition, organ toxicity, black-box warnings, and market withdrawals. Agilent has released a mitochondrial toxicity infographic to help you discover the benefits of novel in vitro strategies for consumer safety. This infographic is designed to help: Gain a historical perspective on mitochondrial toxicity. Understand the importance of testing […]

Download Abcam’s guide to learn more about: How multiplexing generates more insightful data The key principles, benefits and limitations of different multiplex assays How to select the most suitable multiplex assay for your screening program Click here to download

In this technical guide you will learn about: The fully automated method for the high-throughput transformation and growth of bacteria cells How to improve robustness and reproducibility of your experiments How the transformation of DNA into bacteria cells, such as Escherichia coli (E. coli), is an essential molecular biology technique used for both the study […]