Unlocking the value in Data By Dr Amber Salzman In recent years enormous sums have been spent on systems and data management, but are we getting full value from these investments? We discuss here how organisations, scientists and, indeed, vendors themselves must work as one to extract… Read More
Compound Libraries – Cost of ownership By Dr W. Steven Fillers The value of high quality storage and processing of small molecule libraries has recently received increased interest due to a better understanding of the physical properties of DMSO. Automated equipment can now… Read More
By Dr Peter C. Johnson and Dr Alan J. Higgins The pharmaceutical industry has not seen the hoped-for productivity gains from the various omics datastreams over the last decade. This article discusses how systems biology can exploit the natural interlinkages between these datastreams and put in… Read More
The Current Bioinformatics Analytical Software Landscape By Charles Chang With the vast amount of biochemical data generated from experiments conducted by research laboratories around the globe, there is strong demand for software to analyse and manage the data effectively. Analytical software can be utilised… Read More
Virtual Screening – Finding needles in a haystack on a shoestring By Dr David E. Clark, Neil V. Harris, Alan G. Roach and Dr Anthony D. Baxter In recent years, virtual screening (VS) has become an accepted approach to hit-finding alongside biochemical high-throughput screening (HTS). Large pharmaceutical companies… Read More
By Professor Simon Turton, Henry Makansi and Nick Lowcock Business models for emerging bioscience companies come in and out of fashion with some regularity, not always with obvious reason. This article examines what strategies have worked for the leading biopharmaceutical firms in Europe… Read More
Share Share Tweet Email Tools for Structural Genomics – Accelerating the structure pipeline Tools for Structural Genomics – Accelerating the structure pipeline By Dr Lawrence J. DeLucas, Dr Christie G. Brouillette, Dr Kal Ramnarayan and Dr… Read More
Opportunities for the pharmaceutical industry: key biotransformation technologies of the future By Praveen Kaul, Anirban Banerjee and Professor UC Banerjee Biotransformation is a broad and growing field of biotechnology and encompasses both enzymatic and microbial biocatalysis. Progress has been made in research on… Read More
Collaborative eR&D By Richard ORourke In 2001 at the GlaxoSmithKline inaugural shareholder meeting, Chief Executive JP Garnier was clearly not happy with what he regarded as the productivity crisis within the industrys R&D function. He contrasted the consistent growth in investment in R&D… Read More
Growing Market for High Content Analysis Tools By Dr. John Comley and Sandra Fox Two market surveys and a recent major scientific meeting have all highlighted the growing interest in High Content Screening (HCS) and point to the momentum which now surrounds the implementation of high content analysis… Read More
SCAVENGER strategies in organic synthesis – Part Two By Professor Peter Wipf and Dr Claire M. Coleman Part 1 of this article discussed the fundamental principles of the use of scavenging techniques in combinatorial and organic synthesis. Part one of scavenger… Read More
Functional cell-based high throughput drug screening By Professor Daniel T. Chiu and Professor Owe Orwar Cell-based assays are poised to assume an increasingly important role in drug screening and discovery. It is becoming apparent that simple binding assays and in vitro experiments are grossly insufficient for extrapolating… Read More
Making the Most of Drug Discovery Data By Dr Nick Davies and Dr Tim Peakman Discovery scientists in most pharmaceutical companies are struggling with incompatible legacy systems, a growing volume of data and the imminent advent of a product model that will demand much more of them. Read More
Gene Expression: Analysis and Drug R&D By Dr Ralph Sinibaldi It is clear that gene expression profiling systems have a role to play in many facets of drug discovery and development, but several questions remain. We take a look at the use of DNA microarray for gene expression… Read More
Drug Discovery Spending – A Year In Review By Isaac Meek Drug In 2003, the research products market reported revenues of $23 billion, with a 7.5% growth rate over 2002. Although there are many consumers in this market, by far the greatest are drug discovery research groups. Read More
Using RNAi to identify and validate novel drug targets: targeting human kinases with an siRNA library By Andrea Kroenke, Anne Grabner, Dr Michael Hannus, Dr Christoph Sachse, Dr David Dorris and Dr Christophe Echeverri Libraries of siRNAs directed against predefined subsets of genes now offer the capacity… Read More
