App Note: Measure mitochondrial toxicity using primary hepatocytes


Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening.

Download this new App Note to learn:

  • How Agilent Seahorse technology provides a screening solution that is highly sensitive and direct.
  • About the Agilent XF Mito Tox assay as a useful tool in the early detection of mitochondrial toxicity – a critical component of drug development efforts.
  • How to use the Agilent Seahorse XF Mito Tox assay with primary human hepatocytes and predict DILI with sensitivity and ease.
  • How to build a streamlined workflow with the Agilent Seahorse XF Mito Tox assay to understand the mitochondrial dysfunction role in drug-induced hepatotoxicity.

Download now.

Related Articles

Join FREE today and become a member
of Drug Discovery World

Membership includes:

  • Full access to the website including free and gated premium content in news, articles, business, regulatory, cancer research, intelligence and more.
  • Unlimited App access: current and archived digital issues of DDW magazine with search functionality, special in App only content and links to the latest industry news and information.
  • Weekly e-newsletter, a round-up of the most interesting and pertinent industry news and developments.
  • Whitepapers, eBooks and information from trusted third parties.
Join For Free