Drug discovery

In vitro transcription (IVT) can be a complicated reaction. Scaling up this process requires a good understanding of the various reaction parameters that need to be optimised and controlled to give the best result in terms of mRNA yields and quality. In this presentation, a review of the results from scaling up the IVT reaction from […]

Download the new Infographic from NanoTemper: ‘Stability assessment of biologics during early development workflows‘. During early development of biologics, there are a large number of attributes researchers evaluate, but some of the most common centre around stability – asking if a biologic is well-folded, active and pure in its buffer, and whether it remains that […]

During early development of biologics, there are a large number of attributes researchers evaluate, but some of the most common centre around stability – asking if a biologic is well-folded, active and pure in its buffer, and whether it remains that way over time. Biophysical characterisations are valuable for providing this information without using a […]

News round-up for 25-29 September by DDW Digital Content Editor Diana Spencer. Immunotherapy has taken centre stage this week, with several announcements relating to regulatory approval, investment and research results for antibody and CAR-T therapies, perhaps most significantly, encouraging early-stage data for the first in vivo CAR-T therapy. The top stories: €27.3M to advance monoclonal […]

Diana Spencer speaks to Christopher Reid, Professor of Biological and Biomedical Sciences at Bryant University, in Rhode Island, US, to understand the issue of antimicrobial resistance, why there are so few new antibiotics in development and where the drug discovery opportunities can be found. The scale of the crisis In July 2023, a report by […]

This is the latest episode of the free DDW narrated podcast, “Overcoming different barriers in drug discovery”, which covers three articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “Addressing the challenge of salt forms in drug discovery”, “A different approach: reimagining biology”, and “Women in Discovery: championing female […]

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. Download this new […]

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. In this App […]

The Fall issue of Drug Discovery World (DDW) is out now featuring expertise on what spatial biology tells us about drug discovery and disease. Read the digital version free here. Other features in the Fall issue include: How biomarkers can help discover new treatments for women’s health A market report on the innovation taking place across […]

Hosted by DDW and co-sponsored by Benchling and Proscia, “AI and Lab Automation: What are the key benefits and latest innovations?” will be free to attend on 10 October at 7AM PDT / 10AM EST / 3PM BST / 4PM CET. Join this free webinar to learn about the key benefits and latest innovations to […]

Synthetic biology has shown significant potential to the drug discovery sector. Although not a new area of science, the prominence of this technology and its applications – evident during the Covid-19 pandemic – have increased of late. This has created advances in the development of new medicines and our ability to find solutions for unmet medical […]

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week […]

Download this exclusive DDW eReport to learn more about: The global market for synthetic biology: its potential and where innovative drug development is taking place Analysis of regional markets and the key players within the synthetic biology sector How advances in the synthetic biology field are impacting drug discovery – from hit finding and lead generation […]

News round-up for 18-22 September by DDW Digital Content Editor Diana Spencer. As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week we have also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer. […]

A research team from VIB-KU Leuven and the UK Dementia Research Institute has discovered how neurons die in Alzheimer’s disease, opening new pathways for potential future treatments.  A new research paper published in Science illustrates how neurons initiate a programmed form of cell death, known as necroptosis, when they are exposed to amyloid plaques and […]

Biotech company Cytomos has appointed a new Non-Executive Director in a bid to help accelerate plans to brings its cell analysis technology to market.   Dr Sharon Brownlow has joined as Non-Executive Director and will play a key role in helping Cytomos bring its Dielectric Spectroscopy (CDS) platform to market. Cytomos’ CDS platform enables scientists to collect […]