AstraZeneca and Tremont AI have announced a research collaboration to develop and evaluate AI solutions for accelerated safety screening in preclinical toxicologic pathology studies. Assessing the safety of a new drug is one of the most demanding steps before it can reach patients. Toxicologic pathologists… Read More
Download now to read this new Guide from sponsors Apconix. Cardiac safety doesn’t stop with hERG. When it comes to cardiac safety, an integrated approach supports informed decision-making. Discover the importance of the four nonclinical cardiac safety assessments Understand the benefits of each assessment Develop a comprehensive cardiac safety evaluation… Read More
As global regulatory expectations rise around proactive real-world safety monitoring, smaller marketing authorisation holders risk being caught off-guard with their reliance on rudimentary signal detection practices. Current processes may not support the structured, statistics-based approach favoured by larger companies and expected by health authorities. But there are other practical options… Read More
Discover how VOLTA Scanner is transforming cardiac safety testing. This Whitepaper from Lumencor describes an optophysiology instrument, supporting stable, fast, high-resolution toxicity testing and drug development. Download to learn how: VOLTA detects early-after-depolarisations (EADs), and predicts QT/QRS risk Optogenetic pacing improves assay precision Automated, HPT optophysiological screening streamlines… Read More
VOLTA Scanner is transforming cardiac safety testing. This whitepaper describes an optophysiology instrument, supporting stable, fast, high-resolution toxicity testing and drug development. Download to learn how: VOLTA detects early-after-depolarisations (EADs), and predicts QT/QRS risk Optogenetic pacing improves assay precision Automated, HPT optophysiological screening streamlines decisions… Read More
This advertorial for Lumencor appeared in DDW Volume 26 – Issue 2, Spring 2025 Read the digital issue VOLTA is an automated kinetic plate reader for high-throughput cardiac electrophysiology. An optical alternative to patch clamp analyses, it simultaneously scans 96 wells at 10,000 Hz resolution in less than two minutes… Read More
Researchers from the UK’s Drug Safety Research Unit are calling for the robust monitoring of the safety of lecanemab, a new drug to treat Alzheimer’s disease (AD). In a review article, published in the British Journal for Clinical Pharmacology, the researchers discuss the need for ongoing assessment of the safety… Read More
Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug… Read More
Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug… Read More
A tiny human heart model could potentially transform cardiovascular research and enable animal-free drug testing. A team of researchers, led by the Hebrew University of Jerusalem (HU), has developed a self-paced, multi-chambered human heart model, approximately half the size of a rice grain. “Integrating… Read More
In a DDW Sitting Down With podcast with Lu Rahman, Ruth Roberts and Claire Sadler, ApconiX, discuss the benefits of performing a target safety assessment (TSA) during drug discovery and development when a biological target is going to be acted on by a drug. The background In this podcast, Professor… Read More
The European Medicines Agency (EMA) safety committee, the Pharmacovigilance Risk Assessment Committee (PRAC), is reviewing data on the risk of suicidal thoughts and thoughts of self-harm related to GLP-1 receptor agonists. The drugs under review include Ozempic (semaglutide), Saxenda (liraglutide) and Wegovy (semaglutide), used for weight… Read More
The latest sponsored DDW Sitting Down With podcast is now live. Professor Ruth Roberts, Co-Founder ApconiX, and Claire Sadler, Project Toxicologist, discuss the benefits of carrying out a target safety assessment (TSA) during drug discovery and development whenever a biological target is going to… Read More
In the latest sponsored DDW Sitting Down With podcast Professor Ruth Roberts, Co-Founder ApconiX, and Claire Sadler, Project Toxicologist, discuss the benefits of carrying out a target safety assessment (TSA) during drug discovery and development whenever a biological target is going to be modulated. The speakers outline… Read More
As of late December 2022, the US Food and Drug Administration (FDA) no longer needs drugs to be tested in animals to receive approval, according to legislation signed by President Joe Biden1 – the Modernization Act 2.0. This news has been shared widely as a landmark moment, especially in the eyes… Read More
New research, involving 200 professionals in senior roles spanning pharmacovigilance (PV), Drug Safety and Product Safety departments, has found that quality has overtaken cost as a priority in plans for automating adverse event (AE) reporting. John Price, life sciences industry consultant and partner of Arriello, which commissioned this latest research, reports on the findings. Although the Covid-19 pandemic has… Read More
