Drug development

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  Immunotherapy has taken centre stage this week, with several announcements relating to regulatory approval, investment and research results for antibody and CAR-T therapies, […]

DDW has published the latest addition to its Guide Series, ‘Unlocking neuroscience drug discovery’. It covers the way the neuroscience sector is overcoming drug discovery challenges, advances in neuroscience and the era of precision neuroscience. Download to find out: Neuroscience drug discovery advances and challenges and how breakthroughs in this field are helping address areas […]

News round-up for 25-29 September by DDW Digital Content Editor Diana Spencer. Immunotherapy has taken centre stage this week, with several announcements relating to regulatory approval, investment and research results for antibody and CAR-T therapies, perhaps most significantly, encouraging early-stage data for the first in vivo CAR-T therapy. The top stories: €27.3M to advance monoclonal […]

This is the latest episode of the free DDW narrated podcast, “Overcoming different barriers in drug discovery”, which covers three articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “Addressing the challenge of salt forms in drug discovery”, “A different approach: reimagining biology”, and “Women in Discovery: championing female […]

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. Download this new […]

Mitochondrial dysfunction is known to play a central role in drug-induced hepatotoxicity, and thus early detection of mitochondrial toxicity is a critical component of initial drug development efforts. While immortalised cell lines are widely used for in vitro assessment of hepatotoxicity, cryopreserved primary human hepatocytes are a preferred model for drug safety screening. In this App […]

By Katie Gillette, Senior Project Leader, Eliza French, Analyst, Graham Friedman, Analyst, and Olivia Qiu, Associate, DeciBio.  Earlier this year, we explored the microbiome and its role in drug development across various therapeutic areas. This article will focus on one such area of great unmet need and promise: women’s health. We will explore the various […]

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week […]

News round-up for 18-22 September by DDW Digital Content Editor Diana Spencer. As we approach another autumn/winter season in the northern hemisphere, Covid-19 vaccines are once again making the headlines, but in the last week we have also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer. […]

A new cooperative network designed to foster collaboration and boost the sharing of knowledge and expertise for the UK’s advanced therapies sector has been launched.  The ‘Scottish Advanced Therapy Medicinal Products (ATMP) and Vaccines Network’ specifically targets researchers in the north of the UK and will coordinate events, talks from industry leaders and networking opportunities […]

The regulation of cellular bioenergetics is recognised as a key driver of cancer cell proliferation. Identifying key pathways that modulate bioenergetic metabolism is a promising strategy for developing novel therapeutics for cancer treatment. Discover more in this new App Note from Agilent entitled ‘Rapid Bioenergetic Functional Screening of Anticancer Drug Candidates’. Download the App Note […]

The regulation of cellular bioenergetics is recognised as a key driver of cancer cell proliferation. Identifying key pathways that modulate bioenergetic metabolism is a promising strategy for developing novel therapeutics for cancer treatment. In this App Note you will learn: How the Agilent Seahorse XF Real Time ATP rate assay provides a simple robust workflow […]

‘Optimising kinetic assays to avoid avidity effects’ – a new free resource – is now available from Sartorius and DDW. What you will learn: Researchers from ChromoTek discuss the differences between affinity and avidity as measured on the Octet BLI platform Measuring affinity in avidity driven assay orientations Why assay orientation, valency, ligand surface density […]

News round-up for 11-15 September by DDW Digital Content Editor Diana Spencer. Spanning artificial intelligence, theranostics, radiopharmaceuticals, quantum simulation and small regulatory RNA, the top stories this week all cover cutting-edge technologies and techniques making a huge impact on modern drug discovery and development. The headlines: Pharma must embrace an AI future says new report […]

Specialist pharmaceutical company Norgine has appointed Saulo Martiniano as its new Chief Operating Officer (COO).  Martiniano previously worked at L’Oréal and was responsible for leading Global Manufacturing Excellence across 38 plants that included more than 10,000 employees.  Martiniano will now be based in the UK and takes on the responsibility of overseeing Norgine’s global operations […]

What you will learn: Researchers from ChromoTek discuss the differences between affinity and avidity as measured on the Octet® BLI platform Measuring affinity in avidity driven assay orientations Why assay orientation, valency, ligand surface density and non-specific binding matter Recognise and resolve issues arising from interactions that contain a bivalent or multivalent component