The importance of biotherapeutics as a class of drugs continues to increase. Indeed, their low toxicity and high specificity justify their investigation as drug candidates. Yet, quantification studies of biotherapies in complex biological matrices can be very challenging. In particular, high background noise and interferences due to endogenous proteins may compromise the assay.
Dr. Xin Zhang, Senior Application Scientist at SCIEX, helps bioanalysts tackle those very challenges which accompany the quantification of peptide and proteins, whether this be straightforward intact protein and signature peptide analysis workflows or complex workflows.
She presented a free webinar, Sensitive signature peptide quantification using accurate mass spectrometry on December 1, 2021, at 4PM GMT, 9AM PT; 12PM ET; 5PM CET about sensitive signature peptide quantification using accurate mass spectrometry. The event was hosted by DDW and supported by SCIEX.
Who should watch:
Scientists and lab directors at
- Bioanalytical research labs
- Core labs
- Pharmaceutical development labs
What you will learn:
- The fundamental steps to develop a quantitative assay for signature peptides
- An assay development example using high resolution accurate mass spectrometry
- How to address the sensitivity challenges in peptide quantification in a complex matrix
- How to achieve better selectivity between target peptide versus matrix-derived interferences and general high background effects
Watch on demand for free here.