Drug targets

Olink has created a whitepaper which pulls together three recently published research studies highlighting the importance of linking genetic and protein expression data in the context of disease phenotypes in order to identify new, robust drug targets. According to Olink, while many drugs are developed based on genomic findings, it’s common for these drugs to […]

Swedish biotech company Salipro Biotech has announced that the European Patent Office has issued the European Patent No. 3463303, titled “Saposin lipoprotein particles and libraries from crude membranes”. The patent covers the company’s novel method of direct extraction of membrane proteins (DirectMXTM) from cells or crude membranes to enable drug development for challenging drug targets, […]

Michael Smyth is Medical Director at Galapagos UK, responsible for launching innovative therapies in the UK to help change the course of inflammatory disease for patients. Having studied medicine at Liverpool University, one of his personal missions is lifelong learning which is reflected in his role to strive for new treatment options that lead to better […]

Sebastian Nijman, Chief Scientific Officer, Scenic Biotech, explains why harnessing genetic modifiers holds great potential to address the present drug target vacuum and why every drug developer should care about them. According to the National Institute of Health (NIH), approximately 500 of the many thousands of human diseases have an approved treatment. This disappointing result is […]

Do you want to learn about: Trained immunity The role of epigenetic targets in trained immunity Hit discovery through ultra-high throughput screening of large libraries Industry standard Hit-to-Lead biological profiling frameworks Join Dr. Saman Honarnejad, Director Drug Discovery at Pivot Park Screening Centre​ on 14 December 3PM (GMT) for this webinar in which he will […]

One Nucleus has revealed the finalists of its annual BioNewsRound Award, recognising life science companies with exciting developments. The finalists will pitch in the lead up to Genesis 2020 during which the winner will be announced. Companies and research organisations were nominated for their most important updates from the last year. These were assessed based […]

A computational model of a human lung cell has been used to understand how SARS-CoV-2 draws on human host cell metabolism to reproduce by researchers at the University of Warwick, UK. This study helps understand how the virus uses the host to survive and enable drug predictions for treating the virus to be made. Viruses […]

Researchers from the Universities of Melbourne, York, Warwick and Oxford have shed light on how encapsulated viruses like hepatitis B, dengue and SARS-CoV-2 hijack the protein manufacturing and distribution pathways in the cell. They have also identified a potential broad spectrum anti-viral drug target to stop them in their tracks. The findings have been published […]

APEIRON Biologics, a biotech company developing breakthrough therapies to treat cancer and respiratory conditions, has selected Domainex to provide integrated lead optimisation services in order to advance the development of inhibitors for the E3 ubiquitin ligase Cbl-b through small molecule drug discovery. Under the terms of the agreement, Domainex, an integrated drug discovery research service […]

White blood cells called monocytes released into the blood from bone marrow have abnormal features in people who have COVID-19. This is according to a new study by University of Manchester immunologists at the Lydia Becker Institute. The team from the Coronavirus Immune Response and Clinical Outcome (CIRCO) consortium says the abnormalities are greater in […]