Genetics / genomes

Enhertu has been approved in the EU as the first HER2 directed therapy for patients with HER2 low metastatic breast cancer.  The drug is approved as monotherapy for adult patients who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within six months of completing adjuvant chemotherapy.  Enhertu is a […]

By Dr. Oyvind Dahle and Michael R.Pontrelli, Foley & Lardner LLP. The first complete, gapless sequence of a human genome was published 1 April 2022 in a special issue of the journal Science1. While The Human Genome Project mapped about 92% of the human genome two decades ago, sequencing the last 8% of the genome […]

PacBio has expanded a research collaboration with Children’s Mercy Kansas City in an effort to improve scientists’ understanding of the genetic underpinnings of rare diseases.   The collaboration will see Children’s Mercy Kansas City use the multi-omics capabilities of PacBio’s Sequel IIe system in the study of genetic disease. The research will apply direct methylation detection […]

Animals with a large difference in lifespan and size end their natural lives with a similar number of genetic changes, researchers have discovered.   The findings come from a study by the Wellcome Sanger Institute which analysed genomes from 16 species of mammal to understand the role genetic changes play in ageing and the development of […]

Scientists have discovered 75 genetic risk factors for Alzheimer’s disease in research which could help with the development of new therapies.   An international group of scientists from Inserm, Institut Pasteur de Lille, Lille University Hospital, and Université de Lille and the University of Bristol set out to understand the link between certain genetic factors and […]

By John Yoshi Shyu, Ph.D. Corning Life Sciences. Gene therapy – the addition, deletion, or modification of genes in living organisms – has been around, at least in concept, since the 1980s. Gene modification or editing incorporates two main strategies: insertion of novel genetic constructs into existing genes, and gene inactivation or silencing.1 As of […]

Lisa Osborne, CEO at RANA Healthcare Solutions interviews Daniel Kavanagh, PhD, Senior Scientific Advisor, Gene Therapy at WCG. The Covid-19 pandemic has put vaccine development centre-stage. Never have citizens around the world been so focused on the length of time it takes to develop, test, approve, manufacture and distribute new vaccines. This heightened interest is […]

Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analysed the whole genomes of tumour samples from over 2,600 patients with different types of cancer. They identified a high prevalence of genetic diversity within individual tumours, which they further characterised. Their […]

Researchers at the Francis Crick Institute and GSK are extending their collaboration to advance the discovery of new drug targets in a £11.5 million effort. This comes after receiving a ‘Prosperity Partnership’ grant from the Engineering and Physical Sciences Research Council (EPSRC) and matching funds from GSK. Together, the teams will develop and industrialise emerging […]

IDT, genomics solutions provider, has launched a new system to provide an end-to-end solution for characterising and quantifying the full array of on and off-target genome editing events in CRISPR research projects, and other genome editing projects. The system uses IDT rhAmpSeq technology, which is designed to enable accurate amplicon sequencing on Illumina next generation […]