Gene expression

A new paper has solved the 20-year mystery of how epigenetic modifications act as traffic lights to control gene expression and could ultimately speed up the development of a new class of epigenetic cancer drugs.  Epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome. But the new findings answer […]

Researchers say they have successfully used a cell’s natural process for making proteins to ‘slide’ genetic instructions into a cell and produce critical proteins missing from those cells.   If further studies verify the results, this could be a new method for targeting specific cell types for a variety of disorders that could be treated with […]

By Dr Dina Finan, PhD, Product Manager at 10x Genomics and Dr Nick Downey, PhD, NGS Collaborations Lead at Integrated DNA Technologies.  RNA sequencing has become a widely used tool that can explore the transcriptome in a seemingly endless number of applications. While bulk sequencing—or sequencing the transcriptome of an entire sample at once—has contributed to many […]

New research from scientists at the Wellcome Sanger Institute has shown a gene not previously linked to cancer plays a key role in the spread of certain cancers to the lungs. The team found that when the gene LRRN4CL was over-expressed in mice, the skin cancer melanoma was more likely to metastasise to the lungs. The study, […]