Gene expression

DDW Editor Reece Armstrong speaks to Benedikt Nilges, Head of Technology and Data Analytics at OMAPiX about spatial biology’s use in drug discovery and bettering our understanding of disease. RA: How does spatial biology enhance our understanding of the human body and associated diseases? BN: Our bodies consist of an incredibly complex network of about […]

A new paper has solved the 20-year mystery of how epigenetic modifications act as traffic lights to control gene expression and could ultimately speed up the development of a new class of epigenetic cancer drugs.  Epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome. But the new findings answer […]

Researchers say they have successfully used a cell’s natural process for making proteins to ‘slide’ genetic instructions into a cell and produce critical proteins missing from those cells.   If further studies verify the results, this could be a new method for targeting specific cell types for a variety of disorders that could be treated with […]

By Dr Dina Finan, PhD, Product Manager at 10x Genomics and Dr Nick Downey, PhD, NGS Collaborations Lead at Integrated DNA Technologies.  RNA sequencing has become a widely used tool that can explore the transcriptome in a seemingly endless number of applications. While bulk sequencing—or sequencing the transcriptome of an entire sample at once—has contributed to many […]

New research from scientists at the Wellcome Sanger Institute has shown a gene not previously linked to cancer plays a key role in the spread of certain cancers to the lungs. The team found that when the gene LRRN4CL was over-expressed in mice, the skin cancer melanoma was more likely to metastasise to the lungs. The study, […]