Biomarkers

#AI / data analytics / healthtech / informatics #Biomarkers #Drug discovery #SLAS2023 #Therapeutics

Podcast: Acquiring deeper insights and acceleration with AI

Ahead of this year’s SLAS2023 conference in San Diego (which takes place 25 February – 1 March) DDW’s Megan Thomas narrates articles from the DDW SLAS2023 supplement as part of the DDW Events podcast series. This is episode two, Acquiring deeper insights and acceleration with AI. At IBM… Read More

#News

Non-small cell lung cancer
#Biomarkers #Lung cancer #Merck #Oncology #Phase II trial #Precision medicine #Regulatory #Scottish Medicines Consortium (SMC)

SMC approves targeted treatment for lung cancer

Following a resubmission from manufacturer Merck, the Scottish Medicines Consortium (SMC) has now approved Tepmetko (tepotinib) for use on the NHS in Scotland.   It is recommended for the treatment of adult patients with advanced non-small cell lung cancer (NSCLC) harbouring mesenchymal-epithelial transition factor gene (MET) exon 14… Read More

#News #Regulatory

Patient speaking to psychiatrist
#Alta Neuroscience #Biomarkers #Major depressive disorder #Neuroscience #Phase II trial #Precision psychiatry #Psychiatry

Precision drug could redefine depression treatment

A Phase IIa study of Alto Neuroscience’s ALTO-100 has demonstrated clear evidence of efficacy and a favourable safety record in patients with major depressive disorder (MDD).   In the study, patients with a biomarker profile that ties back to a mechanistic understanding of ALTO-100 and depression exhibited a… Read More

#News

#AI / data analytics / healthtech / informatics #Biomarkers #Data management #Drug discovery #Life sciences #RNA sequencing

The latest drug discovery product launches

Several new products for the life sciences sector have been launched over the last month, from biomarker kits to video-based training platforms. DDW provides an update.  Breath Biopsy VOC Atlas – Owlstone Medical  The Breath Biopsy VOC Atlas is a catalogue of validated and quantitated… Read More

#Editor's Choice #News

Human cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing #Webinar

Event: Using native state cells to uncover true biological targets

Extensive manipulation, mechanical force and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is the identification of drug targets that are not relevant to the biological process under study.  Camila Egidio Based on Nakhoda and Olszanski,… Read More

Webinar date:
Brought to you by LevitasBio
#News

Human cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing #Webinar

Why native state cells are needed to uncover true drug targets

Extensive manipulation, mechanical force and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is the identification of drug targets that are not relevant to the biological process under study.  Camila Egidio Based on Nakhoda and Olszanski,… Read More

Webinar date:
Brought to you by LevitasBio
#News

Human cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing #Webinar

Webinar: How single-cell RNA seq has advanced drug discovery

Extensive manipulation, mechanical force and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is the identification of drug targets that are not relevant to the biological process under study.  Camila Egidio Based on Nakhoda and Olszanski,… Read More

Webinar date:
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#News

Human cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing #Webinar

An overview of single-cell RNA sequencing for drug discovery

Extensive manipulation, mechanical force and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is the identification of drug targets that are not relevant to the biological process under study.  Camila Egidio Based on Nakhoda and Olszanski,… Read More

Webinar date:
Brought to you by LevitasBio
#News

Healthy cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing #Webinar

Unperturbed, native state cells uncover biological targets

Extensive manipulation, mechanical force and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is the identification of drug targets that are not relevant to the biological process under study.  Camila Egidio Based on Nakhoda and Olszanski,… Read More

Webinar date:
Brought to you by LevitasBio
#News

Healthy cells
#Biomarkers #Drug discovery #RNA sequencing #Single-cell RNA sequencing

Broadening drug discovery: Use of unperturbed, native state cells to uncover true biological targets at single-cell level

Extensive manipulation, mechanical force, and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is identification of drug targets that are not relevant to the biological process under study. Based on Nakhoda and Olszanski, 2022 (Addressing Recent Failures… Read More

Webinar date:
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#Webinars

CST antibodies using the Cell DIVE multiplexed imaging solution
#Antibodies #Biomarkers #Cancer research #Collaboration #Drug discovery #Partnership

New antibody validation partnership hopes to “power scientific discovery” 

Leica Microsystems and Cell Signaling Technology (CST) have agreed a partnership to validate CST antibodies on the Cell DIVE multiplexed imaging solution.  As an open multiplexing system, Cell DIVE allows researchers to design custom antibody biomarker panels.  James O’Brien, Vice President Life Sciences at Leica… Read More

#Business & Investment #News

Tick bite
#Biomarkers #Genetic profiling #Immunity #Lyme Disease #mRNA #Omics #RNA sequencing

Genetic profiling of Lyme disease could bring new therapeutic targets 

Researchers have identified 35 genes associated with long-term Lyme disease that could potentially be used as biomarkers to diagnose patients with the condition.  The findings, from the Icahn School of Medicine at Mount Sinai in New York and published in the journal Cell… Read More

#News

Biomarkers concept
#Antibodies #Biomarkers #Cell signalling #Cellular imaging #Microsystems

Data collection that empowers scientific discoveries 

Leica Microsystems and Cell Signaling Technology (CST) have announced a partnership to validate CST antibodies on the Cell DIVE multiplexed imaging solution, allowing researchers to design custom antibody biomarker panels.    Backed by a decade of research, the Cell DIVE iterative staining workflow enables the visualisation of over… Read More

#News

#Biomarkers #Cancer research #Click chemistry #Covid-19 #Drug development #Drug discovery #Epstein-Barr virus #Monoclonal antibodies #mRNA #Oncology #Our Future Health #Pancreatic cancer

This week in drug discovery (24-28 October)

News round-up for 24-28 October by DDW Digital Content Editor Diana Spencer  Over the last seven days we’ve seen discoveries that could lead to new treatments for Covid-19, pancreatic cancer and Epstein-Barr virus, as well as the launch of the UK’s largest health research programme and the innovative application of… Read More

#News

Click chemistry
#Biomarkers #Bioorthogonal chemistry #Click chemistry #Genetic engineering #Proteins

‘Click’ chemistry used to tag proteins made by cancer cells 

A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London.   Biomarkers are valuable tools in diagnosing disease or predicting treatment outcomes, but they are… Read More

#Cancer Research #News

Protein molecule
#Biomarkers #Cancer #Diagnostics #Precision medicine #Proteomics

South Korean proteomics company Bertis expands to the US

Bertis, a South Korean proteomics-based precision medicine technology company, has established a US-based wholly-owned entity to expand its global presence. The subsidiary, called Bertis Bioscience, aims to establish a San Diego-based CLIA-certified lab facility in early Q4, 2022. It will offer proteomics-based screening and diagnostic tests, as well as an… Read More

#Cancer Research #News