Cryo-electron microscopy (cryo-EM), a powerful biophysical technique that can analyse molecular assemblies, is changing the paradigm in structure-based drug design. As targets become more challenging, solving structures of drug target molecules or biologics becomes increasingly difficult. Cryo-EM empowers drug discovery teams to take advantage of rational drug design for many more major drug target classes, […]

The AstraZeneca Oxford University vaccine trial has been paused due to illness in a participant. The much-publicised vaccine provoked a T cell response within 14 days of vaccination (white blood cells that can attack cells infected with the SARS-CoV-2 virus), and an antibody response within 28 days. As part of the ongoing randomised, controlled clinical […]

CN Bio has developed single and multi-organ microphysiological systems (MPS) to improve the accuracy and efficiency of drug discovery. It is now collaborating with Imperial College London. The research will harness CN Bio’s Liver-on-Chip technology to advance the understanding of the underlying mechanisms of alcoholic hepatitis and uncover novel targets for drug discovery and development. […]

Dotmatics’ eln.online is a quick start version of its Electronic Laboratory Notebook (ELN). Designed for research organisations at an early stage in their development, eln.online is a new version of the company’s existing ELN Studies Notebook. According to Dotmatics the software can be easily set up. It enables search and capture of experimental data in […]

Scenic Biotech has entered into a multi-year strategic collaboration with Genentech to discover, develop and commercialise novel therapeutics that target genetic modifiers. Genentech is a member of the Roche Group. Genetic modifiers are genes that counteract the effect of a disease-causing gene. They may explain why some people with genetic mutations linked to severe disease […]

Mogrify has won the AstraZeneca Life Science Innovation category of the Business Weekly Awards. The award commends Mogrify in applying its proprietary direct cellular conversion technology to further the cause of life science discovery for the benefit of human healthcare. Prof. Julian Gough, Co-founder and CSO of Mogrify, received the Cambridge Enterprise Academic Entrepreneur of […]

In light of the high failure rate of compounds when they are subjected to clinical testing, we are seeing a renaissance in phenotypic screening in drug discovery. However, most phenotypic screening is based on the use of cellular assays and here we debate the advantages and disadvantages of single-cell versus 3D multi-cell analyses. The phenotypic […]

The recent outbreak of COVID-19 has highlighted the need for fast and efficient development and production of vaccines for a whole gamut of pathogens, old and new. Microfluidics technologies can be used to accelerate the vaccine development process in a number of ways, not least in the directed evolution of the strains and host organisms […]

IDBS has released a fully-featured integration between the E-WorkBook electronic laboratory notebook (ELN) and SCIEX Analyst Software. This expands on IDBS’s existing family of integrations. This new integration aims to strengthen IDBS’ existing preclinical capabilities by seamlessly transferring data, enabling increased regulatory compliance and improved throughput. In response to the call for improved preclinical workflows […]

This webinar, hosted by DDW and presented by Sartorius, will examine T cell exhaustion and how it is recognised as a major challenge in the development of immuno-oncology therapies. A broad term used to describe the loss of effector function due to chronic antigen exposure, it commonly occurs within the tumour microenvironment, impairing the T […]