Cryo-EM has been adopted into drug discovery workflows by the pharmaceutical and biotechnology industries having proved itself capable of delivering atomic resolution structures for key targets, including integral membrane proteins such as GPCRs and ion channels.
More recently, significant improvements in throughput have seen use of the technique expand quickly within the sector. Key to this expansion has been improvements in sample preparation efficiency and reproducibility, which have enabled the investigation of ever more challenging biomolecules.
In this on-demand webinar, hosted by DDW and supported by SPT Labtech, hear from two researchers – Prof Wei-Jen Tang from the University of Chicago and Radhika Malik, Assistant Professor at the Icahn School of Medicine at Mount Sinai – for whom these new methods were important factors in overcoming sample-specific challenges encountered in structural studies of macromolecules with implications for human health.
The presentations are followed by a discussion of the role that new sample preparation modalities have played in facilitating these and other drug discovery projects.
What you will learn:
- The importance of high throughput CryoEM to understanding the dynamic structural behaviour of many potential drug targets
- How CryoEM is increasingly able to provide information on even the most challenging biomolecules, including samples previously too small to be analysed.
- How modern automated sample preparation techniques can help overcome significant data collection challenges