Stem cells

DDW’s Reece Armstrong speaks to Hendrik Streefkerk, Chief Medical Officer and Drug Safety Officer of CellProthera about the company’s cell therapy for acute myocardial infarction (AMI) and why regenerative medicine could be key to treating cardiac diseases.   Based in France, CellProthera is a small, regenerative cell therapy developer that specialises in cardiovascular diseases. The […]

Mark Kotter, Founder and CEO of bit.bio, talks with Reece Armstrong about different approaches to synthetic biology and its applications in programming stem cells into mature, functional human cells for drug discovery and the creation of next generation. In the last 10 years, synthetic biologists have developed new technologies that have led to some of the […]

Download this new scientific Poster from bit.bio, just revealed at ISSCR 2023. You will discover: How precision reprogramming generates consistent, functional human microglia (ioMicroglia) from iPSCs in just 10 days Independent validation that ioMicroglia undergo phagocytosis of both E. coli particles and amyloid beta particles Independent validation that ioMicroglia show a pro-inflammatory cytokine response to […]

In this scientific Poster, just revealed at ISSCR 2023, you will discover: How precision reprogramming generates consistent, functional human microglia (ioMicroglia) from iPSCs in just 10 days Independent validation that ioMicroglia undergo phagocytosis of both E. coli particles and amyloid beta particles Independent validation that ioMicroglia show a pro-inflammatory cytokine response to various disease-relevant stimuli […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. Join DDW for this exclusive […]

This article is sponsored by Charles River. Research tools, safety testing and regenerative medicines – these endless stem cell applications are powering precision, speed, and new modalities in drug development.     Stem cells for use in drug discovery Stem cells are fast becoming an invaluable tool in the drug discovery process. Through the use of human induced […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. Join DDW for this exclusive […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. Join DDW for this exclusive […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. Join DDW for this exclusive […]

Axol Bioscience has signed an exclusive agreement with StrataStem to access and commercialise its collection of Alzheimer’s Disease (AD) patient samples.   Harnessing its stem cell expertise, Axol will reprogramme these patient samples into induced Pluripotent Stem Cells (iPSCs) that can then be differentiated into a range of brain cells, including neurons and neuroinflammatory cells. […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. Join DDW for this exclusive […]

Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function. During this webinar, supported by […]

Scientists are calling for tighter regulation of stem cell treatments, claiming clinics worldwide are offering unproven ‘therapies’ for conditions as varied as hair loss and Parkinson’s. Researchers at the University of Reading and the Universiti Sains Malaysia have identified 114 companies in over 20 countries offering unproven, unregulated, stem-cell derived products to consumers. They are […]

A Phase III clinical trial led by physicians in the US has shown that adding investigational drug motixafortide significantly increases the number of stem cells that can be harvested compared with treatment with the standard agent alone. The standard treatment for patients with multiple myeloma often includes stem cell transplantation in which the patient’s own […]

UK researchers, from the Wellcome Sanger Institute and collaborators, have used human stem cells and neurons to investigate what features influence how well CRISPR activation works for different sets of genes. Published in Molecular Cell, the study explains the rules determining to what extent genes respond to CRISPR activation, ensuring that future research can be […]

An investigational gene therapy for Sanfilippo syndrome – which leads to a form of childhood dementia – has shown promising early results in a proof-of-concept study.  The study found that four out of five patients diagnosed with Sanfilippo have continued to gain cognitive skills in line with development in healthy children after being given the […]