This is the latest episode of the free DDW narrated podcast, titled “UK Spotlight: Innovation and discovery”, which covers three articles written for DDW Volume 24 – Issue 4, Fall 2023. They are called: “Where is the drug discovery expertise happening in the UK?”, “From the top: Dr… Read More
With the use of innovative solubilisation approaches, such as synthetic copolymers, structural biologists can efficiently create soluble membrane proteins optimised for cryo-EM workflows. A new Application Note is now available to download for free, entitled ‘Screening of copolymer nanodiscs with multi-parameter stability characterization on the Prometheus Panta’. In this… Read More
With the use of innovative solubilisation approaches, such as synthetic copolymers, structural biologists can efficiently create soluble membrane proteins optimised for cryo-EM workflows. In this Application Note, learn how to screen for the optimal copolymers using a combination of parameters from the Prometheus Panta instrument for stability characterisation of membrane… Read More
Researchers have discovered that nanoparticles derived from rice bran are both effective and safe for the treatment of cancer. Cancer therapies that employ nanoparticles can specifically target cancer cells, sparing healthy tissue. Recent studies have demonstrated that plant-derived nanoparticles (pdNPs) that have therapeutic effects… Read More
Lung organoids grown by University of Manchester scientists have been shown to mimic the response of animals when exposed to certain nanomaterials. The study at the University’s NanoCell Biology Lab at the Centre for Nanotechnology in Medicine is published in the journal Nano Today. Read More
A new infographic ‘Four methods for thermal stability assessment of therapeutic proteins‘ is now available to download for free. Thermal stability is among the most common critical quality attributes (CQAs) used for early developability assessment of biologics. In this infographic, learn about four methods for thermal stability… Read More
Thermal stability is among the most common critical quality attributes (CQAs) used for early developability assessment of biologics. In this infographic, learn about four methods for thermal stability assessment of proteins – what they measure, what the data tells you, and their benefits and limitations. While each provides unique value,… Read More
Will you be attending SLAS2024 in Boston? This year the programme will feature a track curated by DDW taking place in the Ignite Theater ‘Innovation & technology: from lab to patient’. Co-sponsored by Integra Biosciences and Hamamatsu Corporation, the Ignite Theater will be… Read More
Listen to this article on the DDW Podcast: Megan Thomas talks to Molly Stevens, John Black Professor at Oxford University and Research Director for Biomedical Materials at Imperial College London. MT: Where do you work, and can you tell us what you’re working on at the moment?… Read More
Aviceda Therapeutics has dosed the first patient in its Phase II SIGLEC trial investigating AVD-104 as a treatment for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). AVD-104 is a novel glycan-coated nanoparticle, supported by a strong pre-clinical in vivo efficacy and safety profile. Read More
SiSaf is to collaborate with the University of Leipzig, Germany, to develop targeted micro interfering RNAs (miRNA) for the treatment of cancer, with an initial focus on pancreatic cancer. The collaboration will combine SiSaf’s expertise in RNA delivery using its Bio-Courier silicon-stabilised hybrid lipid nanoparticles (sshLNPs) and… Read More
Researchers have made it possible to see at the nano level where a medicinal drug ends up in the cells and how much of it is needed for optimum treatment. The technique enables the development of new pharmaceuticals and tailored treatments for diseases that have not previously… Read More
Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition. Researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible. … Read More
Here, we speak with two of the keynote speakers at this year’s Drug Discovery 2022, Molly Stevens, Professor of Biomedical Materials and Regenerative Medicine at Imperial College London, and Rab Prinjha, VP Head of Immunology Research Unit at GlaxoSmithKline, about the insights they will be sharing and what they see as… Read More
University of Queensland researchers have pioneered a new chemical process to manufacture molecules that are the building blocks for lifesaving medicines, vaccines and energy storage materials. Professor Matt Trau from UQ’s Australian Institute for Bioengineering and Nanotechnology (AIBN) has been awarded an ARC Laureate Fellowship worth $2.9 million to further… Read More
A potential improved treatment for two of the leading causes of blindness – age and diabetes-related eye problems – has been demonstrated in research involving University of Queensland expert Professor Di Yu of the UQ Diamantina Institute, who collaborated with scientists from the Chinese Academy of Sciences and Beijing Chaoyang… Read More
