Mouse models

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies.   Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas. We’re beginning to see their potential come to fruition, with […]

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. By analysing gene interactions in mice subjected to behavioural tests, the researchers from Korea University Anam Hospital, Konkuk University, and Sahmyook University identified 141 genes primarily linked to immune responses correlating with depressive behaviours. […]

Kiave Yune Ho Wang Yin, PhD, Chief Business Officer at TransCure bioServices explores how humanized mouse models can be used to develop more relevant preclinical studies for IBD treatments and ultimately increase the likelihood of a treatment’s success in clinical trials.  Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis (UC), are a global health […]

Accurate dose prediction for clinical trials is essential to ensure patient safety and trial success. This new whitepaper from the Jackson Laboratory discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models. In this whitepaper you will learn about: The significance of selecting appropriate starting doses in clinical trials. […]

This whitepaper discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models and emphasises the importance of accurate dose prediction to ensure patient safety and trial success. In this whitepaper you will learn about: The significance of selecting appropriate starting doses in clinical trials. Utilising humanised mouse models […]

This paid-for advertorial by Taconic appeared in DDW Volume 24 – Issue 3, Summer 2023 Overcoming challenges in model generation Genetically engineered mouse models are essential tools for biomedical research. Yet when seeking to obtain an existing model, researchers often encounter obstacles related to intellectual property, availability, or licensing. As a result, model generation is an […]

Humanised mouse model CRO TransCure bioServices and South Korean CRO Preclina have agreed a partnership to improve preclinical development services in the APAC region. Drug developers in APAC have typically faced many challenges when it comes to preclinical development, from limited access to animal model providers and poor service offering breadth and capacity, to a […]

This is the latest episode of the free DDW narrated podcast, “Immunotherapy, avelumab and protecting the immunocompromised”, which covers three articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “Mice with humanised immune systems advance cell-based immunotherapy”, “The avelumab story and what it means for urothelial carcinoma”, and “Immunocompromised […]

With an attrition rate of up to 95% for oncology drug development, it is evident that significant barriers still exist when it comes to translating preclinical investigation findings to in-human trials. This new Guide from TransCure bioServices explores how humanized mouse models can help accelerate the successful development of novel, safe, and effective treatments for oncology […]

With an attrition rate of up to 95% for oncology drug development, it is evident that significant barriers still exist when it comes to translating preclinical investigation findings to in-human trials. Our Guide explores how humanized mouse models can help accelerate the successful development of novel, safe, and effective treatments for oncology by generating human-relevant […]

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry’s Pain Research Center. The study, published in the Proceedings of the National Academy of Sciences (PNAS), illustrates how pain […]

Dr Megan MacBride and Dr Caroline Horizny Mitchell, Taconic, examine recent changes to animal testing in drug design. Drug discovery and development is an arduous process that can cost upwards of $2.6 billion and take over 10 years. While the discovery phase – which includes target discovery, target validation, lead compound identification, and lead compound […]

This article is sponsored by Taconic. The cancer therapeutic landscape changed dramatically with the introduction of immune checkpoint inhibitors (ICIs) that target T cells and leverage a patient’s immune system. Success in targeting T cells as immunotherapy has prompted investigators to explore whether other immune cell types can be leveraged to develop efficacious oncology treatments. […]

Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The findings suggest a new approach to treating Alzheimer’s and other neurodegenerative diseases.  Context   Researchers at Washington University School of Medicine in St Louis showed that the tens of trillions of microbes that normally live in […]

Harvard investigators have developed a new cell therapy approach to eliminate established tumours and induce long-term immunity.   In this early research, Khalid Shah, Professor of Neurosurgery at Harvard Medical School and Brigham and Women’s Hospital, and colleagues tested the vaccine in an advanced mouse model of brain cancer glioblastoma, with promising results. The findings are […]

Researchers have identified the genetic links between muscle atrophy and two types of myosin, paving the way for a new disease model for scientific research and potential new treatments.  The synergistic action of the muscle proteins myosin and actin enables skeletal muscle movements. The skeletal muscle myosin heavy chain or “MyHC” is a fundamental component […]