Scientists have taken an important step toward the development of a potential new treatment for treating Shiga toxin-producing E coli (STEC), the bacteria associated with severe food poisoning. The findings – led by the University of Glasgow and published in Antimicrobials and… Read More
This advertorial for Taconic appeared in DDW Volume 26 – Issue 2, Spring 2025 Read the digital issue Taconic in vivo models provide enhanced physiological relevance for translational research. The NOG portfolio offers severely immunodeficient mice enabling engraftment of human hematopoietic stem cells (HSCs) to recapitulate features of the… Read More
A new Whitepaper from Taconic Biosciences is now available to download entitled ‘An Introduction to Humanized Immune System Mouse Models‘. Traditional mouse models have limitations in recapitulating human biology — but humanised immune system (HIS) mice offer a more predictive approach. These advanced models bring you closer to clinical… Read More
Unlock the power of humanised immune system mice. Traditional mouse models have limitations in recapitulating human biology — but humanised immune system (HIS) mice offer a more predictive approach. These advanced models bring you closer to clinical relevance. Download this Whitepaper to discover: The evolution of immunodeficient mice Key humanisation… Read More
A new on-demand webinar is now available from Taconic Biosciences. Join geneticist Bart Smits PhD as he outlines key considerations for designing and maintaining a robust mouse colony to support your preclinical research needs. Dr Bart Smits currently leads the Department of Genetic Sciences and Compliance at Taconic… Read More
Join geneticist Bart Smits, PhD in this exclusive webinar as he outlines key considerations for designing and maintaining a robust mouse colony to support your preclinical research needs. Secure your spot to: Understand the impact of background strain and substrain on mutation expression. Explore effective… Read More
Results of an in vivo mouse colorectal cancer model study have shown a 60% life extension for Oxford Drug Design’s first-in-class approach against multiple tumours. The results follow previous in vivo validation of the therapeutic candidates and have led to… Read More
Data demonstrate that engineered tRNA from Alltrna’s first development candidate restores protein production to clinically meaningful levels in two disease models driven by the same premature termination codon. AP003 is a chemically modified, engineered tRNA oligonucleotide in a clinically validated, liver-directed lipid nanoparticle (LNP) that can readthrough… Read More
According to a 2020 Biotechnology Innovation Organization report, fewer than 8% of drug candidates that enter clinical trials eventually receive regulatory approval. One of the primary reasons for this high failure rate is the poor translatability of preclinical findings, often due to a lack of appropriate mouse models. Read More
This guide explores key considerations for generating and managing genetically engineered mouse models (GEMs) to accelerate and optimise preclinical research programmes. Generating GEMs: three cutting-edge technologies you need to know. Five key components of effective colony management. How integrated solutions can unlock the full potential of preclinical research. Read More
Sophisticated in vivo models are paramount for evolving drug research and developing biologic therapeutics. A new whitepaper from Taconic Biosciences delves into the challenges faced by researchers in sourcing appropriate models and how humanized immune system (HIS) models can provide innovative solutions. You will learn about: The significance of… Read More
Sophisticated in vivo models are paramount for evolving drug research and developing biologic therapeutics. Our whitepaper delves into the challenges faced by researchers in sourcing appropriate models and how humanized immune system (HIS) models can provide innovative solutions. You will learn about: The significance of HIS models in bridging the… Read More
Skye Bioscience has announced preliminary data from a diet-induced obesity (DIO) model in mice, in which its CB1-inhibiting antibody, nimacimab, achieved dose-dependent weight loss of up to 16% compared to vehicle. Skye developed a DIO model using a transgenic mouse expressing the human CB1 receptor… Read More
A new study in mice by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) in New York has identified a promising drug combination for the treatment of muscle-invasive bladder cancer. Rosiglitazone plus trametinib worked synergistically to not only induce tumour cell death, but also shift… Read More
PolTREG has launched a preclinical study with CAR-Treg cells in a humanized mouse model of neuroinflammatory disease. The study will measure the safety and efficacy of the therapy and data is anticipated by March 2025. PolTREG’s CAR-Treg cells are manufactured using the same technology… Read More
Professor Andy Whiting, CEO of Nevrargenics, asks whether animal models should be used as the default regulatory requirement and explores the times to use them. Animal models (AMs) have generally been seen as useful for drug development and biomedical research for many years. They are assumed to closely mimic human… Read More
