Recent Developments in Combinatorial Chemistry By Dr Anthony D Baxter Combinatorial chemistry has advanced significantly from the early 1990s when it was a new science of mainly conceptual interest to today where it has evolved into a key component of the drug discovery industry. Read More
HTS a strategy for drug discovery By Dr AR Knight, Cerebrus Ltd Whichever technologies are implemented, high throughput screening is set to become one of the cornerstones of drug discovery, however deciding which strategy to implement will provide many headaches. This article concentrates on screens identifying the… Read More
By Jennie Gwynn and Peter J Hylands Putting aside the excitement surrounding the human genome, in the near future we may well start to see the emergence of a new class of prescription medicine containing complex mixtures of plant extracts. This article discusses the important role that… Read More
By Matthias Mann, Protein Interaction Laboratory (PIL), University of Southern Denmark Affinity proteomic methods can translate genomic data into validated targets for drug discovery. Baits such as tagged gene product or small molecules obtained from cell-based assays are used to purify interacting proteins. Read More