High throughput screening

Arrayjet and Chemspace have agreed a partnership to augment and streamline Chemspace’s small molecule microarray (SMM) service offering. Chemspace’s compound libraries are now accessible through Arrayjet’s SMM CRO/CMO services for assay development, contract screening and contract array manufacturing. SMMs enable high-throughput screening of compound libraries against targets of interest. Compounds can be printed neat at […]

Sania Therapeutics, a new company focused on developing genetic medicines for neural circuit dysfunction, has launched at the American Society of Gene & Cell Therapy (ASGCT) conference. The company’s approach combines adeno-associated viruses (AAV) in human neural circuits with tuneable conditionally-activated ion channels. This corrects dysfunctional neural excitation. Sania’s technology platforms were first developed at […]

SLAS Europe 2023 will take place 22-26 May in Brussels, Belgium, where attendees will embrace the theme Science Set in Motion. DDW’s Multimedia Editor Megan Thomas explores what to expect from the event. Scientific tracks SLAS Europe 2023 will feature four tracks focused on life sciences and their global impact: Biology Unveiled, Frontiers in Technology, […]

The Carterra 2023 Symposia Series ‘Unlocking High-Throughput Biology and Drug Discovery’ is now open for registrations. Join industry-leading scientists from GSK, Oxford University, LifeArc, Alloy Therapeutics, Sanofi, and Carterra on April 19, 2023 in Cambridge, UK for this one-day, science-filled experience. Learn about the current advancements in high-throughput biology, including applications in antibody discovery, PROTACs, […]

The success of messenger RNA or mRNA vaccines in the fight against the global SARS-CoV-2 crisis brings a new era of vaccine development. In vitro transcription, or IVT, is a complex reaction, requiring key components like an RNA polymerase, nucleotides, and a DNA template to make each mRNA. By partnering with a supplier like Thermo […]

In this listicle, Thermo Fisher Scientific outlines five measures to help you ensure consistency in your workflow and produce reproducible, high-quality batches of IVT mRNA at scale. The success of messenger RNA (mRNA) vaccines in combatting the global SARS-CoV-2 crisis brings a new era of vaccine development. Applications of in vitro transcribed (IVT) RNA in […]

The Tecan Group and Oxford Nanopore Technologies will collaborate to drive easier high throughput nanopore library preparation in an automated, hands-free fashion.   The aim of the partnership is a fully automated workflow for Oxford Nanopore’s Ligation Sequencing Kit XL V14 protocol (LSK114) with Tecan’s DreamPrep NGS solutions.  The LSK114 protocol allows for any fragment length […]

Kristen Hopson, Vice President of Preclinical Discovery and Development at Generate Biomedicines, and Yue Liu, Associate Director, HTS at Generate Biomedicines, reflect on the impact of artificial intelligence (AI), machine learning (ML), cloud computing, and advances in laboratory automation and high-throughput screening (HTS) on life science research. Proteins are the basic building blocks and engines of […]

Ahead of this year’s SLAS2023 conference in San Diego (which takes place 25 February – 1 March) DDW’s Megan Thomas narrates articles from the DDW SLAS2023 supplement as part of the DDW Events podcast series. This is episode four, How machine learning and lab automation are changing the future of protein therapeutics. In this article, […]

Charles River Laboratories and Pioneering Medicines have entered a multi-programme agreement that gives Pioneering Medicines access to artificial intelligence (AI) model Logica.  Through the agreement, Pioneering Medicines will apply Logica across a portfolio of targets with the aim of creating optimised small molecules that will lead to novel therapies for unmet medical needs.  “We are […]

Esperovax and Ginkgo Bioworks have agreed a partnership to develop circular RNAs (circRNAs) for a variety of therapeutic applications.   Initially, the companies will work to develop circRNAs harbouring payloads to specifically target colorectal cancer by inducing cell death only in cancerous cells.  CircRNAs represent an emerging, powerful mechanism for delivering therapeutics and vaccines due to […]

CAR-T cell therapies are a promising approach for treating solid tumours. But identifying appropriate T-cell receptor (TCR) domains that exclusively target tumour antigens remains a challenge. Toxicity, tumour activation, and tumour persistence are significant challenges to using CAR-T cell therapies for solid tumours. In this new on-demand webinar, Twist Bioscience’s CSO, Aaron Sato, will present […]

CAR-T cell therapies are a promising approach for treating solid tumours. But identifying appropriate T-cell receptor (TCR) domains that exclusively target tumour antigens remains a challenge. Toxicity, tumour activation, and tumour persistence are significant challenges to using CAR-T cell therapies for solid tumours. In this webinar, Twist Bioscience’s CSO, Aaron Sato, will present several proof-of-concept […]

PhoreMost and ThinkCyte have entered a strategic research partnership aimed at advancing modern phenotypic drug screening using artificial intelligence (AI).  The partnership leverages both companies’ technologies in high-throughput drug discovery, PhoreMost’s phenotypic screening platform, SITESEEKER, and ThinkCyte’s AI-driven cell characterisation and sorting platform, Ghost Cytometry.  Driven by advances in cell-based phenotypic screening tools and novel […]

GenScript Biotech, a provider of life-science research tools and services, is partnering with Allozymes, a Singapore-based biotech startup, with aims to accelerate the enzyme discovery and development process.  In the partnership, GenScript will provide the mutant libraries construction and expression, while Allozymes will provide ultra-high-throughput screening for applications across various industries, including pharmaceuticals.  Naturally occurring […]

Arndt Asperger, Senior Applications Scientist, Bruker Daltonics and Meike Hamester, Vice President Label-Free Technologies, Bruker Daltonics, examine how challenges in mass spectrometry for high-throughput screening can be overcome using a label-free approach.   Mass spectrometry is inherently appealing for high-throughput screening (HTS), because it avoids certain drawbacks of label-based assays, but long-standing limitations of cost per sample, […]