Genetics / genomics

X-Chem and the Structural Genomics Consortium (SGC) have entered a collaboration aimed at creating new chemical tools to study human proteins. The goal is to generate DNA-encoded library (DEL) screening data for large numbers of under-addressed proteins in the human proteome – ultimately allowing drug discovery and machine learning (ML) experts from around the world […]

Researchers from the Francis Crick Institute, King’s College London and Guy’s and St Thomas’ NHS Foundation Trust in the UK have characterised a specialised type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut. The researchers found that in healthy guts there was a specialised […]

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. The study, by researchers at The Institute of Cancer Research, London, shows that certain characteristics within patients’ primary tumours can predict how they will respond to different treatments […]

Samir Ounzain, PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. The whole world realised the power of RNA when the Covid-19 pandemic brought us the first mRNA-based vaccines. Over the next two decades, it is quite possible that most […]

Reece Armstrong speaks to Neil Dhawan, the Co-founder and CEO of Totus Medicines about the company’s approach to drug discovery using fundamental technologies in chemistry, biology and artificial intelligence (AI). RA: How is Totus Medicines attempting to target untreatable or undruggable diseases? ND: Discovering a highly effective drug is like winning the lottery. If you […]

UK-based precision medicine software provider Lifebit has agreed partnerships with two population genomic initiatives in Mexico and Brazil to help diversify genomic research and reduce health inequality in Latin America. Lifebit’s platform provides a secure way for research organisations to access global biomedical data – helping accelerate precision medicine and drug discovery. The use of […]

Evan Floden, CEO of Seqera Labs examines how data sharing platforms are impacting cancer and genomics research. The tide has been turning in the worlds of diagnostics and drug development. Bioinformatics and genetic sequencing are starting to be placed front and centre of public research programmes as scientists from around the world recognise the substantial […]

A study into long Covid has provided the first detailed genetic insights into the condition and its commonalities with other diseases, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Despite considerable global research, studies have so far failed to identify the detailed genetic risk factors for long Covid, the mechanisms behind the disease, or any common pathophysiology […]

University of Queensland (UQ) researchers have used genetics to reveal that much of the risk of developing the common and sometimes fatal diverticular disease of intestine (DivD) is inherited. The study has identified new drug targets and opened up possibilities for novel treatment strategies. Dr Yeda Wu and Professor Naomi Wray from UQ’s Institute for […]

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  It’s been a fascinating week in drug discovery, as AstraZeneca announced that its Phase III trial of datopotamab deruxtecan did not meet its […]

Camena Bioscience has closed a $10m Series A financing round, which will be used to scale operations and continue development of DNA synthesis platform gSynth. Synthetic genes are widely used by researchers to understand the mechanisms of disease, and in the drug discovery process to combat them. However, the cost, time and accuracy of traditional […]

News round-up for 3-7 July by DDW Digital Content Editor Diana Spencer. It’s been a fascinating week in drug discovery, as AstraZeneca announced that its Phase III trial of datopotamab deruxtecan did not meet its second primary endpoint and saw an 8% drop in its stock market value as a result. In other headline news, […]

PrecisionLife and the University of Oxford have signed a data access agreement to license the Oxford Endometriosis Gene (OXEGENE) dataset to develop new personalised treatments for endometriosis patients. Endometriosis affects 10% of women globally, but on average it takes over seven years for patients to receive a diagnosis. There are currently no approved diagnostic biomarkers […]

New research has found a key human gene responsible for blocking most avian flu viruses from spilling over into people. The international study into the pandemic potential of avian flu, which is led by scientists at the MRC-University of Glasgow Centre for Virus Research (CVR), identified the human gene BTN3A3, which is commonly expressed in […]

The latest eBook by DDW ‘The impact of genomics on drug discovery: Creating new opportunities’ is out now. This 24-page eBook sponsored by The Jackson Laboratory looks at the key use-cases for genomics and how it is improving drug discovery and development projects. Download this exclusive eBook to learn more about: If animal genomics can help find […]

This 24-page eBook sponsored by The Jackson Laboratory looks at the key use-cases for genomics and how it is improving drug discovery and development projects. Download this exclusive eBook to learn more about: If animal genomics can help find therapies for human disease Key challenges and drivers of the genomics market How transcriptomics is driving drug discovery […]