Gene delivery

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development.  AAV […]

Gene delivery technologies company VectorBuilder has opened a new office in Edinburgh, hoping to bolster its presence in the United Kingdom. The new location is part of Edinburgh Technopole, a Pioneer Group in Midlothian Science Zone. “When it comes to published scientific research, the UK is ranked third in the world with nearly 200,000 citable […]

From humble beginnings in the founder’s basement, UK-based Aptamer Group is now supplying its Optimer binders to clients across big pharma. DDW’s Diana Spencer caught up with co-founder and CEO Dr Arron Tolley. DS: What motivated you and Dr David Bunka, CTO, to create Aptamer and did you imagine you would one day be operating on […]

Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition.  Researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible.  The study, led by OSU Associate Professor of Pharmaceutical […]

Vector BioPharma and the Instituto de Biologia Experimental e Tecnológica (iBET) have agreed a multi-phase collaboration to advance the technical development of Vector’s gene delivery platform.  Vector BioPharma’s gene delivery platform combines high-capacity virus-like particles with exogenous, high-avidity adapter proteins.  Lorenz Mayr, CEO at Vector BioPharma, said: “Collaboration with industry-leading R&D institutions and researchers in […]

Researchers have found that a topical gene therapy gel helps heal wounds in patients with life-threatening blistering skin disease epidermolysis bullosa (EB).  People with dystrophic epidermolysis bullosa often suffer from large open wounds that last for years or decades. It’s an intensely painful condition, and medical treatment for it has been limited largely to palliative […]

Researchers say they have successfully used a cell’s natural process for making proteins to ‘slide’ genetic instructions into a cell and produce critical proteins missing from those cells.   If further studies verify the results, this could be a new method for targeting specific cell types for a variety of disorders that could be treated with […]

Electroporation is a highly effective, versatile technique for the delivery of molecular cargo to many different cell types and tissues of biomedical relevance. Despite its efficacy, electroporation is under-utilised because of the perceived initial up-front cost in purchasing an electroporator and its association with high cytotoxicity. Download the new whitepaper from Mirus Bio: Electroporation Made […]

Download the latest Mirus Bio whitepaper to learn about: The differences between gene delivery methods (electroporation, chemical transfection and viral transduction). Optimising electroporation with the Ingenio(R) EZporator(R) Electroporation System. Electroporate multiple cell types with high efficiency and viability. Deliver different molecular cargo.