A major new research study has identified potential new ways to treat the most common type of bowel cancer. The study, conducted by an international research team led by The Institute of Cancer Research, London and RCSI University of Medicine and Health Sciences, provides a roadmap for… Read More
People who show signs of faster biological ageing could be more likely to develop cancer earlier in life, a new study suggests. Scientists from the PROSPECT team, funded by Cancer Grand Challenges, analysed blood samples and health information from more than 164,000 people from the UK and… Read More
A team of researchers from ChristianaCare and the University of Delaware in the US has uncovered that a common genetic mutation in colorectal cancer disrupts the colon’s normal tissue renewal process, causing immature cells to build up, tissue structure to break down and early tumours to form. … Read More
Scientists at The Institute of Cancer Research (ICR), London, have discovered what may cause some treatments to stop working in people living with bowel cancer. The findings could help researchers use information about a person’s cancer to make better use of current treatments and develop more targeted… Read More
Cancer Research UK and partners have committed £5.5 ($7.1) million in funding to form a world-leading research team tasked with making personalised medicine a reality for people with bowel cancer. The CRC-STARS initiative will bring together over 40 research experts from across the UK, Spain, Italy and… Read More
The amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy, new research has revealed. If integrated into the clinic, the researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, say testing for… Read More
Australian researchers have analysed how an antidiabetic treatment could help control the growth of tumours, potentially paving the way for the design of better cancer treatments. The new study investigated what happens when metformin, a type 2 diabetes medication, is used to treat colorectal cancer cells,… Read More
Phase II trial results have shown the superiority of immunotherapy pembrolizumab over chemotherapy when given before bowel cancer surgery. The results were presented by researchers at University College London (UCL) and UCLH at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024. Read More
A novel, multi-specific CD73/PD-1 targeting drug-Fc conjugate (DFC) exhibited robust anti-tumour activity in humanised mouse models of colorectal cancer at low doses, according to data presented at the ESMO Immuno-Oncology (IO) Annual Congress. “We are thrilled to be presenting promising preclinical data on our novel multi-specific… Read More
Chemotherapy becomes less effective because healthy cells push cancer cells to grow more slowly, according to the findings of two studies from University College London (UCL) and Yale University. Bowel cancer kills over 900,000 people a year and is the second highest cause of cancer mortality… Read More
Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs. Using Nobel Prize-winning microscopy techniques, the researchers revealed how the tankyrase protein switches itself on and off… Read More
Cancers can evolve to become more aggressive without relying only on DNA mutations, two major studies have revealed. The research characterises an extra level of control of cancer gene activity within tumours, which the researchers describe as cancer’s ‘dark matter’. The two studies showed how… Read More
