Bacteria

The United States Patent and Trademark Office (USPTO) has granted Gedea Biotech’s patent application 16/753,899 directed to gluconic acid derivatives for preventing and/or treating bacterial infections. The patent can be kept in force until 2038. The specific derivative Glucone-delta lactone (GDL) in pHyph is a well-documented substance with a low risk of developing antimicrobial resistance. […]

Danish biotech MinervaX has launched the first Phase I clinical study in older adults of its novel Group B Streptococcus (GBS) vaccine, at CEVAC (Centre for Vaccinology) in Ghent, Belgium. GBS is a global unmet medical burden and can cause serious illness in people of all ages, worldwide. It is normally associated with infection in […]

RESP-X, Infex Therapeutics’ anti-virulence therapy to treat Pseudomonas aeruginosa (Pa) infections in non-cystic fibrosis bronchiectasis (NCFB) patients, has shown a promising interim safety and tolerability profile in its ongoing first-in-human Phase I clinical trial. The first cohort consisted of eight healthy volunteers who received doses of RESP-X at 1mg/kg. No serious adverse events were reported, […]

University of Queensland (UQ) researchers have led a national study on the four main bacteria that cause sepsis, providing new targets for developing antibiotics. Professor Mark Walker and Professor Mark Schembri from UQ’s Institute for Molecular Bioscience, along with Dr Andre Mu from the University of Melbourne and teams from 23 research organisations around Australia, […]

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. The team used two safeguard methods to prevent the bacteria and their modified genes from escaping into the wild. The work promises to reduce the threats […]

For the first time, researchers have developed an mRNA vaccine that is 100% effective against a type of bacteria that is lethal to humans, paving the way for effective vaccination against antibiotic-resistant bacteria. The study, conducted in an animal model, demonstrated that all treated animals were fully protected against the bacteria. According to the researchers, […]

University of Queensland researchers have identified a pathway in cells that could be used to reprogramme the body’s immune system to fight back against both chronic inflammatory and infectious diseases. Dr Kaustav Das Gupta and Professor Matt Sweet from UQ’s Institute for Molecular Bioscience discovered that a molecule derived from glucose in immune cells can […]

The first patient has been treated in everImmune’s Phase I clinical trial evaluating its oncobiotic drug candidate Oncobax AK in lung and kidney cancer patients.  The aim of the trial is to assess the toxicity and efficacy of Oncobax AK when administered alongside an immunotherapy treatment.  EverImmune plans to recruit a total of 60 patients […]

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. But with hundreds of bacterial species populating our gastrointestinal tract, it’s a daunting task to pinpoint which molecules made by which bacteria affect which biological processes—and how they do so. “Microbiome […]

In this technical guide from Analytik Jena you will learn about: The fully automated method for the high-throughput transformation and growth of bacteria cells How to improve robustness and reproducibility of your experiments How the transformation of DNA into bacteria cells, such as Escherichia coli (E. coli), is an essential molecular biology technique used for both the […]