The advent of immuno-oncology has necessitated changes in the types of animal models used in oncology drug discovery. Syngeneic models—inbred mice bearing an engrafted tumour derived from a genetically identical mouse strain—are invaluable preclinical research tools that enable tumor studies in the context of a complete and functional immune system. These models are powerful tools for studying tumor-immune system interactions and investigation into new immunotherapies.
Syngeneic mouse models for preclinical immuno-oncology
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