New data show that an unprecedented 60% of patients with advanced lung cancer given Lorbrena (lorlatinib) remain alive without disease progression after five years. The trial results also demonstrated an 81% reduction in risk of progression or death and 94% reduction in progression of brain… Read More
Thousands of cancer patients in England are set to gain fast-tracked access to trials of mRNA personalised cancer vaccines following the launch of an NHS trial ‘matchmaking’ service to help find new life-saving treatments. The vaccines being jointly developed by biopharmaceutical companies BioNTech and Genentech are… Read More
Biomica has revealed encouraging initial findings from an ongoing Phase I clinical trial of its microbiome-based immuno-oncology candidate, BMC128, in combination with an anti-PD1 immune checkpoint inhibitor. The trial is assessing the drug in patients with non-small cell lung cancer (NSCLC), melanoma, or renal cell… Read More
A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The three-year survival rate for children with high-grade gliomas, without further complications, is only… Read More
Pheon Therapeutics has completed a $120m Series B financing to fund the development of its pipeline of next generation ADCs for a wide range of hard-to-treat cancers. The new financing will be used to further advance Pheon’s differentiated ADC pipeline through clinical proof of concept. The first three assets are… Read More
Reece Armstrong speaks to Samuel Deutsch, Chief Scientific Officer of Nutcracker Therapeutics about the RNA landscape and how it can benefit the development of immunotherapies. RA: What role does RNA play in the development of effective immunotherapies? SD: The ability of RNA therapies to use the body’s own mechanisms to… Read More
Deepika Khedekar, Associate Centralized Clinical Trial Lead at IQVIA Inc, looks at the challenges of utilising artificial intelligence (AI) in oncology clinical research. Ten million1 people around the world die from cancer each year. Yet, while the number of cancer clinical trials has soared from 19,211 in 2013 to a… Read More
A US study suggests Novo Nordisk’s GLP-1 receptor agonist Ozempic (semaglutide), which is approved as a treatment for diabetes and weight loss (as Wegovy), could reduce the risk of cancer. Ozempic has been in the spotlight recently following study data proving that patients taking it had… Read More
Acepodia has announced promising preliminary data from its Phase I dose escalation clinical trial of ACE1831, an anti-CD20 antibody conjugated allogeneic gamma delta T cell therapy being evaluated in patients with non-Hodgkin’s lymphoma (NHL). One out of five patients demonstrated complete response (CR) and three out… Read More
Lantern Pharma has entered a strategic AI-driven collaboration with French biotechnology company Oregon Therapeutics to optimise the development of its first-in-class protein disulfide isomerase (PDI)1 inhibitor drug candidate XCE853 in novel and targeted cancer indications. Lantern will be leveraging its RADR AI platform to uncover biomarkers and efficacy-associated signatures of XCE853 across solid… Read More
Immune B cells could be used to develop cancer targeting immunotherapies, following new research by scientists at The Institute of Cancer Research, London, the University of Oxford and University of Cambridge. The scientists discovered the role of immune B cells which makes them successful at targeting tumours,… Read More
A new study has revealed that aspirin helps the body’s immune system detect and target cancer cells. The study showed that long-term daily use of aspirin can help to prevent the development and progression of colorectal cancer, but the mechanisms involved remain unclear. To… Read More
A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. As reported by The Guardian, the global Phase III clinical trial is being led by University College London Hospitals NHS Foundation Trust (UCLH) and… Read More
Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer. The researchers from the Francis Crick Institute, the National Cancer Institute (NCI) of the US National Institutes of Health (NIH) and Aalborg University in… Read More
Researchers have discovered that nanoparticles derived from rice bran are both effective and safe for the treatment of cancer. Cancer therapies that employ nanoparticles can specifically target cancer cells, sparing healthy tissue. Recent studies have demonstrated that plant-derived nanoparticles (pdNPs) that have therapeutic effects… Read More
Antiverse is an artificial intelligence (AI)-driven company that specialises in antibody design against difficult-to-drug targets, including G-protein coupled receptors (GPCRs) and ion channels. Murat Tunaboylu, Co-founder and CEO of Antiverse, speaks with Megan Thomas about how AI can advance therapeutic antibody design. Megan T: How is Antiverse using AI in… Read More
