Breakthrough drug discovery research collaboration in obesity

Weight loss and obesity

Flagship Pioneering and ProFound Therapeutics have announced a collaboration to conduct foundational research to identify potential next-generation first-in-class therapies for the treatment of obesity.

The collaboration is the first initiated under Flagship’s Pioneering Medicines strategic partnership with Pfizer announced in July 2023.

Pioneering Medicines, Flagship’s in-house drug discovery and development unit, is responsible for leading the partnership with Pfizer, including driving the exploration process to rapidly surface potential drug development programmes built on Flagship’s diverse bioplatforms and modalities.

John Lepore, CEO of ProFound Therapeutics and Flagship Pioneering CEO-Partner, said: “We have discovered and validated an extensive library of novel proteins that unlock a new universe of possibilities for treating many different diseases, and I’m excited to apply this platform to novel therapies for obesity through this collaboration.”

Paul Biondi, Flagship Executive Partner and President of Pioneering Medicines, said: “This agreement will enable ProFound to explore how its pioneering platform can tackle unmet need in obesity. It is an exciting milestone for the partnership and the pipeline of programmes we are developing to deliver potential new and transformational medicines.”

Charlotte Allerton, Head of Discovery and Early Development, Pfizer, said: “With obesity expected to impact 1.9 billion people globally by 2035, it is critical to continue breakthrough discovery research that may lead to new, first-in-class therapies that help address current gaps in care.”

Megan Thomas, Multimedia Editor, DDW

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