Author Archives: Megan Thomas

#Narrated podcasts

The next steps in the fight against cancer

This is the latest episode of the free narrated DDW podcast, “The next steps in the fight against cancer”. It covers two articles written for Volume 22, Issue 4 – Fall 2021 of DDW. They are called “Accelerating research: the path forward for treating rare cancers” and “… Read More

#Podcasts

#Cancer #Cancer research #Immuno-oncology #Immunotherapy #Molecular Biology #Oncology #Rare disease

Podcast: The next steps in the fight against cancer

This is the latest episode of the free DDW podcast, “The next steps in the fight against cancer”. It covers two articles written for Volume 22, Issue 4 – Fall 2021 of DDW. They are called “Accelerating research: the path forward for treating rare cancers” and “Inside combination… Read More

#News

#Clinical trials #Rare disease

Positive Phase I results for rare disease inhibitor 

Affibody’s licensee Rallybio Corporation has announced positive topline results from a Phase I single ascending dose study in healthy participants of RLYB116, a novel, potentially long-acting, subcutaneously administered inhibitor of complement factor 5, or C5, in development for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) and generalised… Read More

#News

#Biologics #Biotechnology #Funding #Seed funding #Therapeutics

How will $41 million be used to fight chronic and age-related diseases? 

Juvena Therapeutics, a biotechnology company scaling a computational platform to map the therapeutic potential of secreted proteins, has raised $41 million in an oversubscribed Series A, bringing its total funding to $50 million. The new funding will power the expansion of Juvena’s drug discovery platform and advance the company’s… Read More

#Business & Investment #News

#Biotechnology #Collaboration #Drug targets #Therapeutics

Collaboration to stabilise a challenging drug target  

Swedish biotech company Salipro Biotech has entered into a research collaboration and license agreement with Sanofi on the discovery of therapeutic biologics against a challenging drug target.  The collaboration brings together Salipro Biotech’s services in developing stable antigens of GPCRs, ion channels and transporters via its proprietary… Read More

#News

#Biologics #Cell and gene therapy #Clinical research #Comment #FDA #Regulatory

The significance of FDA industry guidance on cell and gene therapies 

On 4 November 2022, the FDA’s Center for Biologics Evaluation and Research released guidance for the industry on studying multiple versions of a cellular or gene therapy (CGT) product in an early-phase clinical trial in a single disease1. This guidance finalises the draft guidance of the same… Read More

#Exclusive Content #Opinion #Regulatory

#Cancer #Cancer research #Carbon emissions #Covid-19 #Drug development #Drug discovery #Graft vs Host Disease #Monkeypox #Sustainability

Latest industry updates for the DDW Highlights series

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  This week we learned the shocking statistic that… Read More

#News

#DDW Highlights podcast

DDW Highlights: 14 November 2022

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  This week we learned the shocking statistic that a third of scientific… Read More

#Podcasts

Biomarkers concept
#Antibodies #Biomarkers #Cell signalling #Cellular imaging #Microsystems

Data collection that empowers scientific discoveries 

Leica Microsystems and Cell Signaling Technology (CST) have announced a partnership to validate CST antibodies on the Cell DIVE multiplexed imaging solution, allowing researchers to design custom antibody biomarker panels.    Backed by a decade of research, the Cell DIVE iterative staining workflow enables the visualisation of over… Read More

#News

#In Conversation Series

A novel phenotypic approach to CNS drug discovery  

The newest addition to the free DDW podcast is the In Conversation With series, where DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business.    In this latest episode, DDW’s Megan Thomas speaks with… Read More

#Podcasts

#AI #Drug development #Drug discovery #Enzymes #Metabolomics

AI development duo to advance drug-metabolising enzymes 

Optibrium and Lhasa, developers of software and artificial intelligence (AI) solutions for drug discovery and development, have published a peer-reviewed study, Predicting Regioselectivity of AO, CYP, FMO and UGT Metabolism Using Quantum Mechanical Simulations and Machine Learning, where the team combined existing experimental results, quantum mechanics and… Read More

#Business & Investment #News

#Cancer research #Cancer vaccine #Immuno-oncology #Immunology / Virology & Vaccines #mRNA #mRNA-based vaccines

Merck and Moderna to jointly develop personalised cancer vaccine 

Merck has exercised its option to jointly develop and commercialise personalised cancer vaccine (PCV) mRNA-4157/V940 pursuant to the terms of its existing collaboration and license agreement with Moderna.   mRNA-4157/V940 is currently being evaluated in combination with KEYTRUDA, Merck’s anti-PD-1 therapy, as adjuvant treatment for patients with high-risk… Read More

#Cancer Research #News

#Data #Diagnostics #Genetics / genomics #Healthcare #Public health #Rare disease #Whole genome sequencing

Personalising WGS doubles diagnosis of rare diseases 

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases.  Context   In 2018, the UK’s department of health announced an NHS Genomic Medicine… Read More

#News

Genomics
#Biotechnology #Comment #Data #Gene editing #Genetics / genomics #Genome sequencing #Healthcare #Public health #Research #Whole genome sequencing

Why genomic healthcare data matters in the development of new therapies 

Genomic healthcare data is critical to identify disease risk, ancestry, traits and response to medicines and aids in the development of new targeted therapies – precision medicines. DDW’s Megan Thomas observes developments of accessibility in this sector and the potential impact.  The origins  One might… Read More

#Exclusive Content #Opinion #Trends & Analysis

#Covid-19 #Geographic atrophy #Immunology / Virology & Vaccines #Malaria #Neuroscience #Psychedelics

Catch up on the latest DDW Highlights episode

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  In a week that saw magic mushrooms making the… Read More

#News