Alliance hopes to automate nanopore library preparation

DNA sequencing

The Tecan Group and Oxford Nanopore Technologies will collaborate to drive easier high throughput nanopore library preparation in an automated, hands-free fashion.  

The aim of the partnership is a fully automated workflow for Oxford Nanopore’s Ligation Sequencing Kit XL V14 protocol (LSK114) with Tecan’s DreamPrep NGS solutions. 

The LSK114 protocol allows for any fragment length of DNA to be sequenced, which can range from cell-free DNA to amplicons to any length DNA fragments, from 200 base pairs to more than 100kb.  

Sequencing native, long fragments of DNA is beneficial to generate more comprehensive insights into the genome – which often contain methylation, repetitive patterns of sequences or larger-scale genetic variants – as well as reaching parts of the genome that cannot be resolved by using traditional short read technologies in the same single sequencing run.  

Having complete genome assemblies is necessary to ensure better understanding of chromosome function, human disease, and genomic variation, which will translate in future to better prediction and management of diseases.

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