The advent of immuno-oncology has necessitated changes in the types of animal models used in oncology drug discovery.

Syngeneic models — inbred mice bearing an engrafted tumour derived from a genetically identical mouse strain — are invaluable preclinical research tools that enable tumour studies in the context of a complete and functional immune system. These models are powerful tools for studying  tumour-immune system interactions and investigation into new immunotherapies.

Taconic’s white paper takes a closer look at the benefits of syngeneic tumour models and provides:

• An overview of syngeneic tumour models and their importance for immuno-oncology studies
• A brief history of syngeneic models
• The specific differences between syngeneic and humanised models and how this affects their suitability for particular research studies
• The essential considerations to account for in a successful syngeneic tumour study, including genetic background, health status, and the microbiome

Authors: Caroline Horizny, PhD and Philip Dubé, PhD, Taconic Biosciences

To download the white paper click here