Researchers have captured the first-ever high-resolution images of yellow fever virus (YFV), which could pave the way for vaccine design. Scientists at the University of Queensland, Australia, revealed structural differences between the vaccine strain (YFV-17D) and the virulent, disease-causing strains of the virus. Researchers combined yellow fever’s structural… Read More
This eBook highlights recent examples of how cryo-EM and structural insights are being used across various therapeutic modalities to advance drug discovery pipelines. Structure-based drugs have two times the rate of clinical success at 50% of preclinical time and cost. Download this eBook to see the impact of cryo-EM on:… Read More
Two studies have uncovered how combining a reovirus with targeted cancer drugs can dramatically boost immune responses and tumour destruction – offering a promising route to more effective, personalised cancer therapies. Researchers at The Institute of Cancer Research, London, have shown that this combination involving virotherapy can… Read More
Ark Biopharmaceutical (ArkBio) says it has successfully dosed all participants in a Phase I clinical study of AK0610, a fully human monoclonal antibody designed to prevent respiratory syncytial virus (RSV) infection. The treatment offers a potential a new option for preventing RSV infection for vulnerable infants susceptible… Read More
Interim analysis of the Phase III PURPOSE 1 trial indicates that Gilead Sciences twice-yearly injectable HIV-1 capsid inhibitor, lenacapavir, demonstrates 100% efficacy for the investigational use of HIV prevention in cisgender women. PURPOSE 1 met its key efficacy endpoints of superiority of twice-yearly lenacapavir to once-daily… Read More
The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM). AFM has emerged in the United States… Read More
Researchers at the Francis Crick Institute in the UK have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease infection. The aryl hydrocarbon receptor (AHR) is a protein found at barrier sites like the gut… Read More
