Protein chemistry / Proteomics

The Genie in the Test Tube – From Gene to Gene Therapy: Part 1 By Dr Jan Steiner For thousands of years, medicine was a descriptive art, with treatments for disease arising from astute observation and trial and error. The rise of modern forms of biological sciences, especially the developments in molecular biology over the […]

Emerging therapeutic vaccines By Marc Hertz, Soren Mouritsen and Anand Gautam The excitement over the past 30 years for immunotherapy of cancer and other diseases has not led to the expected clinical successes. Over-enthusiasts predicted a cure for cancer with the initial development of monoclonal antibody technology, and later the ‘magic bullets’ or toxin-labelled antibodies. […]

HTS a strategy for drug discovery By Dr AR Knight, Cerebrus Ltd Whichever technologies are implemented, high throughput screening is set to become one of the cornerstones of drug discovery, however deciding which strategy to implement will provide many headaches. This article concentrates on screens identifying the interaction of small molecules with protein targets rather […]

By Jennie Gwynn and Peter J Hylands Putting aside the excitement surrounding the human genome, in the near future we may well start to see the emergence of a new class of prescription medicine containing complex mixtures of plant extracts. This article discusses the important role that plants can play in the search for new […]

The Future Role of CROs By John M Hall PhD and Ludo Reynders PhD The increasing reliance by big pharmaceutical companies on CROs presents a mixture of challenges and opportunities for the industry. Given that the majority of customers are global in their reach, the CRO industry must be prepared to match that reach. Edmund […]

By Matthias Mann, Protein Interaction Laboratory (PIL), University of Southern Denmark Affinity proteomic methods can translate genomic data into validated targets for drug discovery. Baits such as tagged gene product or small molecules obtained from cell-based assays are used to purify interacting proteins. These proteins are then identified by high sensitivity, high throughput mass spectrometric […]