Preclinical investigations

A new study has demonstrated the ability of an experimental regenerative medicine to restore bone in an animal.  Bone loss is a part of ageing that compromises quality of life and movement in many older people, but regenerative treatments to improve their health and well-being have been limited.  The preclinical study, led by Lankenau Institute […]

University of Queensland researchers have identified a pathway in cells that could be used to reprogramme the body’s immune system to fight back against both chronic inflammatory and infectious diseases. Dr Kaustav Das Gupta and Professor Matt Sweet from UQ’s Institute for Molecular Bioscience discovered that a molecule derived from glucose in immune cells can […]

A novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, has significantly improved anti-tumour responses in preclinical models of pancreatic cancer.  In the study, published in Nature Cancer, researchers at The University of Texas MD Anderson Cancer Center used comprehensive immune profiling in mouse and human pancreatic cancers to systematically identify […]

Researchers have shown that the medication saracatinib shows promise as a treatment for idiopathic pulmonary fibrosis (IPF).   Saracatinib worked as well or better than two approved drugs at reducing tissue scarring in preclinical models of IPF according to the study published in the American Journal of Respiratory and Critical Care Medicine.   Researchers at National Jewish […]

DDW Editor Reece Armstrong explores some of the trends that will be featured in sessions throughout ELRIG Drug Discovery 2022 and the news behind them. Taking place at the ExCel in London from 4-5 October, ELRIG Drug Discovery 2022 is set to provide visitors with access to the latest trends, technologies and expertise driving the life sciences […]

BioIVT has acquired XenoTech, a provider of products and services for preclinical testing that specialises in ADME, DMPK and DDI testing of potential drug candidates.  Through the acquisition, BioIVT aims to expand the portfolio of research models and services that are available to its clients to support their R&D function.   “XenoTech has a well-established and excellent reputation […]

Effective preclinical assessment of drug safety and efficacy is essential to help reduce the risk of drug-induced toxicity and late-stage drug attrition. Current preclinical tests for safety depend on in vivo testing in higher-order species to achieve translational accuracy; however, animal models are expensive and do not adequately recapitulate human physiology due to species differences. […]