Immunology

Amphista Therapeutics, a company focused on the development of next generation targeted protein degradation (TPD) therapeutics, has signed a strategic collaboration and license agreement with Bristol Myers Squibb.   The companies will work together to discover and develop small molecule protein degraders. Bristol Myers Squibb will be granted a global exclusive license to the degraders developed and will […]

Chiedzo Mpofu, Vice President, Global Medical Affairs Head, Immunology, at AbbVie, talks to Lu Rahman about our understanding of auto-immune disease and how AbbVie is continuing to innovate in this field. “Immune mediated diseases are a diverse group of conditions that share common inflammatory pathways,” says Chiedzo Mpofu, Vice President, Global Medical Affairs Head, Immunology, […]

Featuring Specialty Spotlight on Immunology, the magazine is available to download and read for free on the DDW App.    Key features of the spring issue include:  Can age-related disease be a thing of the past? Cell & Gene Therapies: Opportunities for Innovation; Animal Research: Reinventing the Norm, plus exclusive interviews and articles on genomics, biomarkers and the microbiome.    Exclusive DDW & SLAS Europe supplement    […]

A new app note, brought to you by BellBrook Labs and supported by DDW, is available to download for free here.  Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterisation of small molecule modulators have […]

Researchers at the Francis Crick Institute and King’s College London have identified how specialist immune cells, called gamma delta T cells (γδ T cells), sense the body’s status quo, enabling them to assess the health of surface tissues and even protect against cancer-causing DNA damage.  Context  Most T cells are present in the blood and […]

A new app note, brought to you by BellBrook Labs and supported by DDW, is available to download for free here.  Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterisation of small molecule modulators have […]

AstraZeneca has added a novel target for idiopathic pulmonary fibrosis (IPF) to its drug development portfolio, discovered using BenevolentAI’s platform. This is reportedly the second novel target from the collaboration that has been identified, validated, and selected for AstraZeneca’s portfolio.   The collaboration  BenevolentAI’s collaboration with AstraZeneca currently focuses on discovering potential new treatments for IPF and chronic kidney […]

Scientists at the Francis Crick Institute have uncovered biological processes key to regulating immune cells that can cause allergic reactions unless closely controlled, which they hope could help expose what goes wrong when the body develops allergies or goes into anaphylaxis.  Background  IgE antibodies are present at very low numbers in the immune system, and unlike […]

Genoskin, a biotechnology company using live ex vivo human skin to test therapeutic and non-therapeutic products, has launched Mantis, a new spatial biology imaging platform dedicated to skin immunology. This new offer was developed by Genoskin’s recently appointed CSO Dr. Nicolas Gaudenzio and his team at Inserm.   What is Mantis?   Mantis is a spatial biology solution designed to analyse human skin and […]

Scientists at the Francis Crick Institute have found how the immune system triggers an ‘emergency’ dendritic cell response during infection, with dendritic cells at the site of infection being reinforced by new cells which travel from the bone marrow.   Dendritic cells have an important role in the immune system, detecting infectious bacteria, fungi or viruses […]