Immunology

As experimental data becomes bigger and more complex, scientists are challenged to make discoveries faster, consistently document and analyse their work, and easily collaborate across an organisation and with external partners. Electronic lab notebooks (ELN) provide access to all collaborators 24/7, wherever they are and whether they are employees or at contract organisations. If an […]

Mouse models with human immune cell engraftment provide platforms to evaluate compounds to treat a variety of human diseases. Humanised PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for […]

This whitepaper, brought to you by The Jackson Laboratory will teach: The benefits of the JAX NSGTM-MHC I/II KO mouse platform humanised with pre-characterised PBMCs How this platform can support a wide range of immunological studies, especially those containing T cells responses The versatility of this platform to various research disciplines

Professor Dr Cornelis (‘Kees’) Melief has been awarded the 2022 Pedro J Romero Service to JITC Award by the Society for Immunotherapy of Cancer (SITC).  The Award recognises individuals who have made immeasurable contributions and demonstrated outstanding commitment to the Journal for Immunotherapy of Cancer (JITC) and will be presented at the SITC’s 37th Annual […]

Researchers at the Francis Crick Institute in the UK, have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer some protection against new virus variants, common colds, and help prepare for future pandemics. Developing a vaccine that provides protection against a number of […]

Amphista Therapeutics, a company focused on the development of next generation targeted protein degradation (TPD) therapeutics, has signed a strategic collaboration and license agreement with Bristol Myers Squibb.   The companies will work together to discover and develop small molecule protein degraders. Bristol Myers Squibb will be granted a global exclusive license to the degraders developed and will […]

Chiedzo Mpofu, Vice President, Global Medical Affairs Head, Immunology, at AbbVie, talks to Lu Rahman about our understanding of auto-immune disease and how AbbVie is continuing to innovate in this field. “Immune mediated diseases are a diverse group of conditions that share common inflammatory pathways,” says Chiedzo Mpofu, Vice President, Global Medical Affairs Head, Immunology, […]

Featuring Specialty Spotlight on Immunology, the magazine is available to download and read for free on the DDW App.    Key features of the spring issue include:  Can age-related disease be a thing of the past? Cell & Gene Therapies: Opportunities for Innovation; Animal Research: Reinventing the Norm, plus exclusive interviews and articles on genomics, biomarkers and the microbiome.    Exclusive DDW & SLAS Europe supplement    […]

A new app note, brought to you by BellBrook Labs and supported by DDW, is available to download for free here.  Clinical trials continue to determine whether therapeutic modulation of kinases can be used to suppress the immune system in autoimmune diseases or stimulate for antiviral and cancer immunotherapy. The discovery and characterisation of small molecule modulators have […]

Researchers at the Francis Crick Institute and King’s College London have identified how specialist immune cells, called gamma delta T cells (γδ T cells), sense the body’s status quo, enabling them to assess the health of surface tissues and even protect against cancer-causing DNA damage.  Context  Most T cells are present in the blood and […]