Ageing

An international research team is the first to use artificial intelligence (AI) analysis to identify dual-purpose target candidates for the treatment of cancer and ageing. Researchers from the University of Oslo, University of Chicago Pritzker School of Medicine, and Insilico Medicine used Insilico’s AI target discovery engine, PandaOmics, to analyse transcriptomic data derived from 16,740 […]

Rejuvenate Biomed, a clinical-stage company advancing therapeutics to delay the onset of age-related diseases, has completed a six-week clinical proof-of-mechanism study with lead candidate RJx-01 for the treatment of sarcopenia.   Sarcopenia is a musculoskeletal disease characterised by the progressive loss of skeletal muscle strength and mass, which manifests chronically with age or as an […]

HKG Epitherapeutics is a biotechnology company developing novel tools for the early detection of cancer and promoting healthy aging. Founder Dr Moshe Szyf Founder shares the potential of harnessing precision medicine.  Embarking on a new era of medicine  The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the […]

Three drugs that could help stave off the effects of ageing have been discovered using artificial intelligence (AI), a study by Edinburgh researchers suggests. Findings suggest the drugs can safely remove defective cells – known as senescent cells – linked to conditions including cancer, Alzheimer’s disease and declines in eyesight and mobility. While previous studies […]

This is the latest episode of the free DDW narrated podcast, “The impact of technology on drug discovery”. It covers two articles written for Volume 23, Issue 2 – Spring 2022 of DDW. They are called “Talking Tech” and “Rejuvenation biotech: Can this company make age a thing of the past?” With Covid-19 taking so […]

New data suggest that AKL Therapeutics’ investigational oral osteoarthritis (OA) drug APPA may have a dual effect on age-related cellular senescence. Senescence, a process in which cells stop dividing, plays a major role in the development of many age-related diseases, including OA. The study, using a human chondrocyte (cartilage-forming) cell line, was carried out at […]

Listen to this article on the DDW Podcast: Kizoo Technology Capital has a clear aim – to develop drugs that abate or cure age-related diseases. Lu Rahman spoke to owner, Michael Greve to find out more about this exciting work that aims to make age-related therapies affordable for everyone. Kizoo is investing €300 million in a […]

Animals with a large difference in lifespan and size end their natural lives with a similar number of genetic changes, researchers have discovered.   The findings come from a study by the Wellcome Sanger Institute which analysed genomes from 16 species of mammal to understand the role genetic changes play in ageing and the development of […]