Handbook for the modern antibody development process

The process of antibody discovery and development into a clinical candidate is one full of twists, turns and offshoots, yet one that an increasing number of researchers and companies, both small and large, have successfully navigated. This eBook released by Twist Biopharma is designed to be used as a handbook for the modern antibody development process.

At least 570 mAbs have already been progressed to the clinic by commercial companies. Each one has been on a long journey of development, with most companies taking approximately 12 years to move from the first patent filing to FDA approval. The multi-year journey may feel overwhelming, but it can be broken up into short-term goals and milestones.

As recently as the past decade, much has changed in antibody discovery, optimisation, and development. New techniques have made this entire process more rapid, cost-effective, and targeted. This guide is here to help you throughout this journey.

In this eBook you will learn how to identify and functionally validate which proteins or biological targets are key to a specific disease; discover an antibody that binds and modulates the function of your target; optimise antibody leads for greater affinity, potency, and developability; and finalise preclinical studies and collect supporting data for investigational new drug submission and clinical advancement.

Download the eBook.

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