Connecting teams and designsets across the DMTA cycle

A team working in a laboratory

This paid-for advertorial by Cresset appeared in DDW Volume 25 – Issue 3, Summer 2024.

Earlier this year, DDW hosted a webinar, ‘Enhancing collaboration in drug discovery – a biotech perspective’, supported by Cresset. The event emphasised the importance of creating a solid infrastructure within any discovery project to enable close collaboration with external partners to effecively track molecules and ideas.

Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations. Harnessing skills and knowledge from distributed teams can create challenges for efficiently managing the ideation process and prioritisation, assignment and delivery of agreed targets.

Torx Software® is a web-based platform that drives collaboration and productivity in small molecule drug discovery by connecting teams and and tracking designsets (a combination of hypotheses and compounds) across the entire DMTA (design, make, test, analyse) cycle. The cloud-native Torx platform can facilitate real-time collaboration with internal and external collaborators, simplified communication and secure workflow management.

The webinar featured Dr David Hollinshead, Technical Director, Elixir Software and Torx Software, and Dr Andrew Griffin, Senior Vice President, Chemistry, Pretzel Therapeutics.

Dr Hollinshead began by introducing Torx Make for DMTA chemistry, a collaboration between Cresset and Elixir Software, explaining how the platform has evolved over the years, and the benefits it offers in tracking the progress and delivery of agreed synthesis targets.

He and Dr Griffin then went on to discuss Dr Griffin’s own experience of using the software, and the benefits of being able to collaborate with colleagues and external partners remotely in real time. Dr Griffin said that the company and its chemistry partners have found the system easy to set up and intuitive to use with little training required, even when different partners need access to a variety of data.

He then explained that at Pretzel the software is primarily used as a place to collect all design ideas, prioritise those to a set of compounds and then send on to the relevant external partners, although the potential functionality is much wider. 

From the automated and visual alert features, partners can be notified by email when, for example, a compound is added or a status changes, and visually alerted within the application. This circumvents the need for other external communication and the avoidance of potential confusion or duplication.

Rounding up the main part of the webinar, Dr Hollinshead concluded that Torx Make provides secure, real-time chemistry-aware communication across project teams to avoid information fracture, connecting all stakeholders, facilitating meetings, and saving time and money.

Following the presentation, audience questions included: 

  • Can I export data from Torx?
  • What happens to information once you stop working with a partner?
  • Can you export data to compare how different collaborators are performing?

Watch on demand.

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