Cell Guidance Systems, a specialist in the control, manipulation, and monitoring of cells and biotech company Manchester Biogel have launched an adaptable environment for 3D cell culture.
PODS-PeptiGels combines the benefits of two existing cell culture technologies – synthetic peptide hydrogels (PeptiGels) and a range of sustained release growth factors (PODS).
PODS-PeptiGels incorporates Cell Guidance Systems’ POlyhedrin Delivery System (PODS) and Manchester BioGel’s biologically relevant hydrogels (PeptiGels). The kit enables researchers to mix and match over 70 growth factors, combined with hundreds of combinations of hydrogels, each with mechanical and biomimetic tuneability, to suit the aims of their research.
PeptiGel hydrogel is produced using synthetic peptides reducing batch variations and enables reproducible results. The PODS crystal protects the growth factor cargo allowing sustained release over a longer period, thereby reducing the frequency of media changes required and minimising growth factor concentration cycles.
Dr Michael Jones, CEO of Cell Guidance Systems, said: “We are excited to launch PODS-PeptiGels with Manchester BIOGEL. Combining the benefits of PeptiGel and PODS technologies provides researchers with a simple and repeatable, physiologically relevant, cell matrix that produces consistent results in addition to reducing hands-on time.”
Dr Donald Daley, CEO of Manchester BIOGEL, added: “Batch-to-batch variation of hydrogels is a big issue and our synthetic PeptiGels overcome this by eliminating variation making it easier to compare results. PeptiGels are functionalised synthetic platforms that support cell growth and are also free from animal origin. This combined with recombinant growth factors that do not degrade quickly due to the PODS technology from Cell Guidance Systems, makes for a powerful 3D cell culture solution that can be scaled up to high throughput, if required, whilst producing consistent and accurate results.”